发明授权
- 专利标题： Oligonucleotide analogs having modified dimers
- 专利标题（中）： 具有改性二聚体的寡核苷酸类似物
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申请号： US10195211申请日： 2002-07-15
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公开(公告)号： US06849723B2公开(公告)日： 2005-02-01
- 发明人: Phillip Dan Cook , Muthiah Manoharan , Balkrishen Bhat
- 申请人： Phillip Dan Cook , Muthiah Manoharan , Balkrishen Bhat
- 申请人地址： US CA Carlsbad
- 专利权人： ISIS Pharmaceuticals, Inc.
- 当前专利权人： ISIS Pharmaceuticals, Inc.
- 当前专利权人地址： US CA Carlsbad
- 代理机构： Isis Patent Department
- 主分类号： C07H21/00
- IPC分类号： C07H21/00 ; C12N15/113 ; C12Q1/68 ; C07H21/02 ; C07H21/04
摘要：
Modified dimers having a ribose sugar moiety in the 5′ nucleoside and a 2′ modified sugar in the 3′ nucleoside are provided. The modified dimers are useful in the preparation of oligonucleotide analogs having enhanced properties compared to native oligonucleotides, including increased nuclease resistance, enhanced binding affinity and improved protein binding.
公开/授权文献
- US20030181693A1 Oligonucleotide analogs having modified dimers 公开/授权日：2003-09-25