The present invention relates to an asymmetric porous polytetrafluoroethylene membrane comprising a dense skin layer and a continuously foamed porous layer, (1) the dense skin layer having a surface roughness Ra of 20 to 165 nm; (2) the dense skin layer having a contact angle for water of 120 to 135°; (3) the porous layer having a maximum pore diameter of 0.03 to 1.0 μm; and (4) the membrane having a total porosity of 20 to 70%. The asymmetric porous PTFE membrane has an ability to separate each liquid component from a liquid-liquid homogeneous mixture in addition to known properties such as water permeability resistance, gas permeability, sealing property and electric property, wherein change of these properties over time is small.