发明授权
- 专利标题： Protein having hemolytic activity and gene encoding the protein
- 专利标题（中）： 具有溶血活性的蛋白质和编码蛋白质的基因
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申请号： US09979275申请日： 2001-03-21
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公开(公告)号： US06855803B2公开(公告)日： 2005-02-15
- 发明人: Hiroshi Nagai , Terumi Nakajima , Kyoko Kuroda
- 申请人： Hiroshi Nagai , Terumi Nakajima , Kyoko Kuroda
- 申请人地址： JP Osaka
- 专利权人： Suntory Limited
- 当前专利权人： Suntory Limited
- 当前专利权人地址： JP Osaka
- 代理机构： Crowell & Moring LLP
- 优先权： JP2000-078967 20000321
- 国际申请： PCTJP01/02209 WO 20010321
- 国际公布： WO0170799 WO 20010927
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A01N63/00 ; A61K35/56 ; A61K38/00 ; A61K39/395 ; A61P7/02 ; A61P7/04 ; C07K14/435 ; C07K16/18 ; C12N1/15 ; C12N1/19 ; C12N1/21 ; C12N5/10 ; C12N15/12 ; C12P21/02 ; C12P21/08 ; C07K14/00 ; C07K1/00
摘要：
Novel proteins having hemolytic activity giving the new approach of development of the drugs, and having the following property are provided: (1) having hemolytic activity; (2) having a molecular weight of about 50,000 Da (determined by SDS gel electrophoresis); and (3) having an amino acid sequence represented by any of SEQ ID NO 1 and SEQ ID NO 2 as a partial amino acid sequence represented by the following amino acid sequences (1) and (2); Amino acid sequence (1): Tyr-Arg-Asp-Gln-Glu-Leu-Glu-Asp-Asn-Val-Lys Amino acid sequence (2): Lys-Trp-Pro-Asp-Tyr-Phe-Val-Tyr-Met-Glu-Ser-Ser-Ala-His-Gly-Tyr-Ile-Arg (wherein, an amino acid residue is written by the 3 letters notation defined by IUPAC and IUB) obtained from nematocyst of Carybdea alata.
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