利索-全球专利检索

  1. 登录
  2. 注册
发明授权
US06861419B2 Substituted 1, 4-thiazepine and analogs as activators of caspases and inducers of apoptosis and the use thereof 失效
取代的1,4-硫氮杂和类似物作为半胱天冬酶和凋亡诱导剂的活化剂及其用途

Substituted 1, 4-thiazepine and analogs as activators of caspases and inducers of apoptosis and the use thereof
摘要：
The present invention is directed to substituted 1,4-thiazepine and analogs thereof, represented by the general Formula I: wherein the dashed lines, A1, A2, A3, X1 and R1 are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of capases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要（中）：

本发明涉及由通式I表示的取代的1,4-硫氮杂和其类似物：其中虚线A 1，A 2，A 3，X 1和R 3， 1>。 本发明还涉及发现具有式I的化合物是抑制剂的活化剂和凋亡诱导剂。 因此，本发明的胱天蛋白酶和细胞凋亡诱导剂的激活剂可用于诱导异常细胞发生不受控制的生长和扩散的各种临床病症中的细胞死亡。

公开/授权文献
信息查询
Espacenet
0/0