发明授权
US06866844B2 Precursor N-acetylgalactosamine-4-sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme
有权
前体N-乙酰半乳糖胺-4-硫酸酯酶，使用所述酶的处理方法和用于产生和纯化所述酶的方法
- 专利标题： Precursor N-acetylgalactosamine-4-sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme
- 专利标题（中）： 前体N-乙酰半乳糖胺-4-硫酸酯酶，使用所述酶的处理方法和用于产生和纯化所述酶的方法
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申请号： US10290908申请日： 2002-11-07
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公开(公告)号： US06866844B2公开(公告)日： 2005-03-15
- 发明人: Minmin Qin , John M. Henstrand , Gary N. Zecherle , Dan J. Wendt , Wai-Pan Chan , Lin Chen , Paul A. Fitzpatrick , Christopher M. Starr
- 申请人： Minmin Qin , John M. Henstrand , Gary N. Zecherle , Dan J. Wendt , Wai-Pan Chan , Lin Chen , Paul A. Fitzpatrick , Christopher M. Starr
- 申请人地址： US CA Novato
- 专利权人： Biomarin Pharmaceutical Inc.
- 当前专利权人： Biomarin Pharmaceutical Inc.
- 当前专利权人地址： US CA Novato
- 代理机构： Marshall, Gerstein & Borun LLP
- 主分类号： A61K38/46
- IPC分类号： A61K38/46 ; C12N9/16 ; A23J1/00 ; C12N1/20 ; C12N15/00
摘要：
The present invention provides a highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase and biologically active mutants, fragments and analogs thereof as well as pharmaceutical formulations comprising highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase. The invention also provides methods for treating diseases caused all or in part by deficiencies in human N-acetylgalactosamine-4-sulfatase including MPS VI and methods for producing and purifying the recombinant precursor enzyme to a highly purified form.
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