发明授权
- 专利标题: Method of targeting conjugate molecules to mitochondria
- 专利标题(中): 将缀合物分子靶向线粒体的方法
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申请号: US09448312申请日: 1999-11-23
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公开(公告)号: US06867197B1公开(公告)日: 2005-03-15
- 发明人: Robert E. Davis , Soumitra S. Ghosh , John S. Kiely
- 申请人: Robert E. Davis , Soumitra S. Ghosh , John S. Kiely
- 申请人地址: US CA San Diego
- 专利权人: Mitokor
- 当前专利权人: Mitokor
- 当前专利权人地址: US CA San Diego
- 代理机构: Seed Intellectual Property Law Group, PLLC
- 主分类号: A61K38/00
- IPC分类号: A61K38/00 ; A61K48/00 ; C07D219/08 ; C07K14/47 ; C12N9/02 ; C12Q1/68
摘要:
The present invention relates to genetic mutations in mitochondrial cytochrome c oxidase genes that segregate with Alzheimer's disease (AD). The invention provides methods for detecting such mutations, as a diagnostic for Alzheimer's Disease, either before or after the onset of clinical symptoms. The invention further provides treatment of cytochrome c oxidase dysfunction.
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