发明授权
US06887983B2 Purified 20 kDA presenilin 2 C-terminal fragment and methods of screening for compounds that inhibit proteolysis of presenilin 2
失效
纯化的20kDA早老素2 C-末端片段和筛选抑制早老素蛋白水解的化合物的方法2
- 专利标题： Purified 20 kDA presenilin 2 C-terminal fragment and methods of screening for compounds that inhibit proteolysis of presenilin 2
- 专利标题（中）： 纯化的20kDA早老素2 C-末端片段和筛选抑制早老素蛋白水解的化合物的方法2
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申请号： US09065902申请日： 1998-04-24
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公开(公告)号： US06887983B2公开(公告)日： 2005-05-03
- 发明人: Rudolph E. Tanzi , Tae-Wan Kim
- 申请人： Rudolph E. Tanzi , Tae-Wan Kim
- 申请人地址： US MA Boston
- 专利权人： The General Hospital Corporation
- 当前专利权人： The General Hospital Corporation
- 当前专利权人地址： US MA Boston
- 代理机构： Sterne Kessler Goldstein & Fox, PLLC
- 主分类号： A01K67/027
- IPC分类号： A01K67/027 ; A61K38/00 ; A61P25/28 ; C07K14/47 ; C07K16/18 ; C12N5/10 ; C12N15/02 ; C12N15/09 ; G01N33/15 ; G01N33/50 ; G01N33/53 ; C07K16/00
摘要：
The present invention relates, in general, to presenilin 2 proteolytic fragments. In particular, the present invention relates to a purified 20 kDa presenilin 2 C-terminal fragment (PS2-CTF); purified nucleic acid molecules coding for the 20 kDa PS2-CTF protein; cells containing the nucleic acid molecules; non-human organisms containing the nucleic acid molecule; antibodies having specific binding affinity to the 20 kDa PS2-CTF; hybridomas containing the antibodies; methods of detecting 20 kDa PS2-CTF in a sample; diagnostic kits; methods for screening compounds that inhibit proteolytic processing of presenilin 2 in a cell, isolated compounds that inhibit proteolytic processing of presenilin 2 in a cell, and a method of inhibiting apoptotic cell death by preventing proteolytic cleavage of presenilin 2 at a cleavage site which generates a 20 kDa C-terminal fragment.