发明授权
- 专利标题： Production of tetravalent antibodies
- 专利标题（中）： 生产四价抗体
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申请号： US09238741申请日： 1999-01-28
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公开(公告)号： US06897044B1公开(公告)日： 2005-05-24
- 发明人: Gary R Braslawsky , Nabil Hanna , Kandasamy Hariharan , Michael J LaBarre , Tri B Huynh
- 申请人： Gary R Braslawsky , Nabil Hanna , Kandasamy Hariharan , Michael J LaBarre , Tri B Huynh
- 申请人地址： US CA San Diego
- 专利权人： Biogen Idec, Inc.
- 当前专利权人： Biogen Idec, Inc.
- 当前专利权人地址： US CA San Diego
- 代理机构： Pillsbury Winthrop LLP
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K39/395 ; A61K47/48 ; A61P1/00 ; A61P11/00 ; A61P11/02 ; A61P11/06 ; A61P17/00 ; A61P35/00 ; A61P37/02 ; A61P37/08 ; C07K16/28 ; C07K16/46 ; C12P21/08 ; C12N15/00
摘要：
The present invention relates to a novel process for the preparation of biologically active antibody dimers in a pharmaceutically acceptable composition. The dimers can be composed of two antibody molecules having the same antigen binding specificity and linked through reducible, disulfide, or a non-reducible thioether, bond (homodimer). Alternatively, the dimers can be composed of two different antibody molecules having binding specificity for two distinct antigens (heterodimer). These dimers are useful for inducing hyper-cross-linking of membrane antigens. The present invention further relates to the use of biologically active antibody dimers for the preferential killing or inhibition of selected cell populations in the treatment of diseases such as cancer and autoimmune disorders.
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