Invention Grant
- Patent Title: Processing method of lactionization in the preparation of statins
- Patent Title (中): 他汀类药物制剂的加工方法
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Application No.: US10295300Application Date: 2002-11-14
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Publication No.: US06906204B2Publication Date: 2005-06-14
- Inventor: Kwang-hyeg Lee , Jin-wan Kim , Kwang-do Choi , Sang-ho Lee , Hong-suk Cho
- Applicant: Kwang-hyeg Lee , Jin-wan Kim , Kwang-do Choi , Sang-ho Lee , Hong-suk Cho
- Applicant Address: KR Seoul
- Assignee: CJ Corp.
- Current Assignee: CJ Corp.
- Current Assignee Address: KR Seoul
- Agency: Swanson & Bratschun, L.L.C.
- Priority: KR10-2001-0075991 20011203
- Main IPC: C07D309/10
- IPC: C07D309/10 ; A61K31/366 ; A61P3/06 ; A61P43/00 ; C07D309/30
Abstract:
The present invention relates to a processing method for preparing lovastatin and simvastatin which comprises the steps of (1) performing lactonization of mevinic acid and its homologous compounds in the presence of a mixed organic solvent without an acid catalyst through nitrogen sweep; and (2) making crystals. In the process of the present invention, lovastatin and simvastatin highly purified can be produced in a high yield and especially, heterodimers formed as a by-product can be reduced remarkably. Therefore, the processing method of the present invention can be convenient and economical.
Public/Granted literature
- US20030109723A1 Processing method of lactionization in the preparation of statins Public/Granted day:2003-06-12
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