公开(公告)号：US06906204B2

公开(公告)日：2005-06-14

申请号：US10295300

申请日：2002-11-14

申请人： Kwang-hyeg Lee ,  Jin-wan Kim ,  Kwang-do Choi ,  Sang-ho Lee ,  Hong-suk Cho

发明人： Kwang-hyeg Lee ,  Jin-wan Kim ,  Kwang-do Choi ,  Sang-ho Lee ,  Hong-suk Cho

IPC分类号： C07D309/10 ,  A61K31/366 ,  A61P3/06 ,  A61P43/00 ,  C07D309/30

CPC分类号： C07D309/30

摘要： The present invention relates to a processing method for preparing lovastatin and simvastatin which comprises the steps of (1) performing lactonization of mevinic acid and its homologous compounds in the presence of a mixed organic solvent without an acid catalyst through nitrogen sweep; and (2) making crystals. In the process of the present invention, lovastatin and simvastatin highly purified can be produced in a high yield and especially, heterodimers formed as a by-product can be reduced remarkably. Therefore, the processing method of the present invention can be convenient and economical.

摘要翻译： 本发明涉及一种制备洛伐他汀和辛伐他汀的加工方法，该方法包括以下步骤：（1）通过氮气吹扫在无酸催化剂的混合有机溶剂的存在下进行乙酸及其同系化合物的内酯化; 和（2）制造晶体。 在本发明的方法中，可以高产率地制备高度纯化的洛伐他汀和辛伐他汀，特别是作为副产物形成的异二聚体可以显着降低。 因此，本发明的处理方法可以方便和经济。