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公开(公告)号：US06756390B2
公开(公告)日：2004-06-29
申请号：US10628210
申请日：2003-07-29
申请人： Seong Hwan Cho , Yong Sik Youn , Yun Taek Jung , Choong Sil Park , Hyuk Koo Lee , Kwang Hyeg Lee , Eun Ju Jeong , Young Hoon Kim , Hae Tak Jin , Jun Hee Cheon , Sung Hak Lee , Sung Hak Jung , Dong Kwon Lim , Kyu Jeong Yeon , Yun Cheul Kim , Kyung Mi Park , Hyun Suk Kang
发明人： Seong Hwan Cho , Yong Sik Youn , Yun Taek Jung , Choong Sil Park , Hyuk Koo Lee , Kwang Hyeg Lee , Eun Ju Jeong , Young Hoon Kim , Hae Tak Jin , Jun Hee Cheon , Sung Hak Lee , Sung Hak Jung , Dong Kwon Lim , Kyu Jeong Yeon , Yun Cheul Kim , Kyung Mi Park , Hyun Suk Kang
IPC分类号： A61K3144
CPC分类号： C07D211/90
摘要： Disclosed are a novel organic acid salt of amlodipine with superb physicochemical properties, its preparation method, and a pharmaceutical composition containing the same as a therapeutically active ingredient.
摘要翻译： 公开了具有极好物理化学性质的氨氯地平的新型有机酸盐及其制备方法以及含有其作为治疗活性成分的药物组合物。
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公开(公告)号：US06906204B2
公开(公告)日：2005-06-14
申请号：US10295300
申请日：2002-11-14
申请人： Kwang-hyeg Lee , Jin-wan Kim , Kwang-do Choi , Sang-ho Lee , Hong-suk Cho
发明人： Kwang-hyeg Lee , Jin-wan Kim , Kwang-do Choi , Sang-ho Lee , Hong-suk Cho
IPC分类号： C07D309/10 , A61K31/366 , A61P3/06 , A61P43/00 , C07D309/30
CPC分类号： C07D309/30
摘要： The present invention relates to a processing method for preparing lovastatin and simvastatin which comprises the steps of (1) performing lactonization of mevinic acid and its homologous compounds in the presence of a mixed organic solvent without an acid catalyst through nitrogen sweep; and (2) making crystals. In the process of the present invention, lovastatin and simvastatin highly purified can be produced in a high yield and especially, heterodimers formed as a by-product can be reduced remarkably. Therefore, the processing method of the present invention can be convenient and economical.
摘要翻译： 本发明涉及一种制备洛伐他汀和辛伐他汀的加工方法，该方法包括以下步骤：（1）通过氮气吹扫在无酸催化剂的混合有机溶剂的存在下进行乙酸及其同系化合物的内酯化; 和（2）制造晶体。 在本发明的方法中，可以高产率地制备高度纯化的洛伐他汀和辛伐他汀，特别是作为副产物形成的异二聚体可以显着降低。 因此，本发明的处理方法可以方便和经济。
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公开(公告)号：US06903124B2
公开(公告)日：2005-06-07
申请号：US10628268
申请日：2003-07-29
申请人： Seong Hwan Cho , Yong Sik Youn , Yun Taek Jung , Choong Sil Park , Hyuk Koo Lee , Kwang Hyeg Lee , Eun Ju Jeong , Young Hoon Kim , Hae Tak Jin , Jun Hee Cheon , Sung Hak Lee , Sung Hak Jung , Dong Kwon Lim , Kyu Jeong Yeon , Yun Cheul Kim , Kyung Mi Park , Hyun Suk Kang
发明人： Seong Hwan Cho , Yong Sik Youn , Yun Taek Jung , Choong Sil Park , Hyuk Koo Lee , Kwang Hyeg Lee , Eun Ju Jeong , Young Hoon Kim , Hae Tak Jin , Jun Hee Cheon , Sung Hak Lee , Sung Hak Jung , Dong Kwon Lim , Kyu Jeong Yeon , Yun Cheul Kim , Kyung Mi Park , Hyun Suk Kang
IPC分类号： C07D211/90 , A61K31/44 , C07D213/80
CPC分类号： C07D211/90
摘要： Disclosed are a novel organic acid salt of amlodipine, its preparation method, and a pharmaceutical composition containing as a therapeutically active ingredient the same.
摘要翻译： 公开了一种氨氯地平的新型有机酸盐及其制备方法以及含有作为治疗活性成分的药物组合物。
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公开(公告)号：US06649775B2
公开(公告)日：2003-11-18
申请号：US10200174
申请日：2002-07-23
申请人： Kwang-Hyeg Lee , Jin-Wan Kim , Myeong-Sik Yoon , Kwang-Do Choi , Sang-Ho Lee , Hong-Suk Cho
发明人： Kwang-Hyeg Lee , Jin-Wan Kim , Myeong-Sik Yoon , Kwang-Do Choi , Sang-Ho Lee , Hong-Suk Cho
IPC分类号： C07D30910
CPC分类号： C07D309/30
摘要： The present invention relates to a process for preparing lovastatin and simvastatin which comprises (1) performing step of a lactonization of mevinic acid and analog thereof compounds in the presence of a dehydrating agent and without an acid catalyst under nitrogen sweep; and then (2) making step of crystals at a high temperature. In the process of the present invention, lovastatin and simvastatin highly purified can be produced in a high yield and especially, heterodimers formed as a by-product can be reduced in an amount remarkably. Therefore, the process of the present invention is convenient and economical.
摘要翻译： 本发明涉及一种制备洛伐他汀和辛伐他汀的方法，该方法包括：（1）在脱水剂存在下，在氮气吹扫下，不用酸催化剂进行乙酸及其类似物的内酯化步骤; 然后（2）在高温下进行晶体化步骤。 在本发明的方法中，可以高产率地制备高度纯化的洛伐他汀和辛伐他汀，特别是可以显着降低作为副产物形成的异二聚体。 因此，本发明的方法是方便和经济的。
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公开(公告)号：US07288652B2
公开(公告)日：2007-10-30
申请号：US10536492
申请日：2003-11-25
申请人： Jin Wan Kim , Kwang Do Choi , Jee Woong Lim , Kwang Hyeg Lee , Sang Ho Lee
发明人： Jin Wan Kim , Kwang Do Choi , Jee Woong Lim , Kwang Hyeg Lee , Sang Ho Lee
IPC分类号： C07D401/00 , C07D405/00 , C07D403/00 , C07D409/00 , C07D411/00
CPC分类号： C07D409/04
摘要： Provided is a method for preparing oltipraz. The method includes reacting methyl 2-methyl-3-(pyrazin-2-yl)-3oxopropionate with phosphorus pentasulfide in the presence of a mixed solvent of toluene and xylene, followed by recrystallization.
摘要翻译： 提供了制备奥替普拉的方法。 该方法包括在甲苯和二甲苯的混合溶剂存在下，使2-甲基-3-（吡嗪-2-基）-3-氧代丙酸甲酯与五硫化二磷反应，然后重结晶。
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公开(公告)号：US20060106079A1
公开(公告)日：2006-05-18
申请号：US10536492
申请日：2003-11-25
申请人： Jin Kim , Kwang Dong Choi , Jee Woong Lim , Kwang Hyeg Lee , Sang Ho Lee
发明人： Jin Kim , Kwang Dong Choi , Jee Woong Lim , Kwang Hyeg Lee , Sang Ho Lee
IPC分类号： A61K31/416 , C07D403/02
CPC分类号： C07D409/04
摘要： Provided is a method for preparing oltipraz. The method includes reacting methyl 2-methyl-3-(pyrazin-2-yl)-3oxopropionate with phosphorus pentasulfide in the presence of a mixed solvent of toluene and xylene, followed by recrystallization.
摘要翻译： 提供了制备奥替普拉的方法。 该方法包括在甲苯和二甲苯的混合溶剂存在下，使2-甲基-3-（吡嗪-2-基）-3-氧代丙酸甲酯与五硫化二磷反应，然后重结晶。
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公开(公告)号：US06890944B2
公开(公告)日：2005-05-10
申请号：US10628209
申请日：2003-07-29
申请人： Seong Hwan Cho , Yong Sik Youn , Yun Taek Jung , Choong Sil Park , Hyuk Koo Lee , Kwang Hyeg Lee , Eun Ju Jeong , Young Hoon Kim , Hae Tak Jin , Jun Hee Cheon , Sung Hak Lee , Sung Hak Jung , Dong Kwon Lim , Kyu Jeong Yeon , Yun Cheul Kim , Kyung Mi Park , Hyun Suk Kang
发明人： Seong Hwan Cho , Yong Sik Youn , Yun Taek Jung , Choong Sil Park , Hyuk Koo Lee , Kwang Hyeg Lee , Eun Ju Jeong , Young Hoon Kim , Hae Tak Jin , Jun Hee Cheon , Sung Hak Lee , Sung Hak Jung , Dong Kwon Lim , Kyu Jeong Yeon , Yun Cheul Kim , Kyung Mi Park , Hyun Suk Kang
IPC分类号： C07D211/86 , C07D211/90 , A61K31/44 , C07D213/80
CPC分类号： C07D211/90
摘要： Disclosed are a novel organic acid salt of amlodipine, its preparation method, and a pharmaceutical composition containing the same as a therapeutically active ingredient.
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公开(公告)号：US07329780B2
公开(公告)日：2008-02-12
申请号：US10582106
申请日：2004-12-09
IPC分类号： C07C303/40 , C07C311/37
CPC分类号： C07C303/40 , C07B2200/07 , C07C311/46
摘要： Provided is a method of preparing an optically pure compound having formula 1 or its salts. The method includes: reacting (R)-2-(4-methoxy-3-aminosulfonyl-phenyl)-1 -methylethylamine or its salts with a compound selected from the group consisting of chloroacetic acid, bromoacetic acid, fluoroacetic acid, iodoacetic acid, α-halogenoacetic acid anhydride, and α-halogenoacetyl halide in the presence of a base or an acylating agent.
摘要翻译： 提供制备具有式1或其盐的光学纯化合物的方法。 该方法包括：使（R）-2-（4-甲氧基-3-氨基磺酰基 - 苯基）-1-甲基乙胺或其盐与选自氯乙酸，溴乙酸，氟乙酸，碘乙酸， α-卤代乙酸酐和α-卤代乙酰卤在碱或酰化剂的存在下反应。
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公开(公告)号：US07015238B2
公开(公告)日：2006-03-21
申请号：US10652417
申请日：2003-08-29
申请人： Dong Kwon Lim , Hyuk Koo Lee , Hea Ran Suh , Seong Hwan Cho , Kwang Hyeg Lee , Yun Cheul Kim , Sung Hak Jung , Sung Hak Lee , Hyun Suk Kang , Kyung Mi Park , Yun Taek Jung , Jun Hee Cheon , Choong Sil Park , Yong Sik Youn , Young Hoon Kim , Kyu Jeong Yeon , Myeong Yun Chae , Hae Tak Jin
发明人： Dong Kwon Lim , Hyuk Koo Lee , Hea Ran Suh , Seong Hwan Cho , Kwang Hyeg Lee , Yun Cheul Kim , Sung Hak Jung , Sung Hak Lee , Hyun Suk Kang , Kyung Mi Park , Yun Taek Jung , Jun Hee Cheon , Choong Sil Park , Yong Sik Youn , Young Hoon Kim , Kyu Jeong Yeon , Myeong Yun Chae , Hae Tak Jin
IPC分类号： C07D211/80 , A61K31/47
CPC分类号： C07D211/90
摘要： A novel crystalline organic acid salt of amlodipine having improved physiochemical properties, a preparation method thereof and a pharmaceutical composition comprising the same are provided.
摘要翻译： 提供具有改善的生理化学性质的新颖的氨氯地平结晶有机酸盐，其制备方法和包含其的药物组合物。
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公开(公告)号：US06846931B2
公开(公告)日：2005-01-25
申请号：US10642754
申请日：2003-08-19
申请人： Yong Sik Youn , Seong Hwan Cho , Choong Sil Park , Yun Cheul Kim , Dong Kwon Lim , Sung Hak Jung , Sung Hak Lee , Hyun Suk Kang , Kyung Mi Park , Yun Taek Jung , Young Hoon Kim , Kyu Jeong Yeon , Myeong Yun Chae , Hae Tak Jin , Hea Ran Suh , Kwang Hyeg Lee , Hyuk Koo Lee
发明人： Yong Sik Youn , Seong Hwan Cho , Choong Sil Park , Yun Cheul Kim , Dong Kwon Lim , Sung Hak Jung , Sung Hak Lee , Hyun Suk Kang , Kyung Mi Park , Yun Taek Jung , Young Hoon Kim , Kyu Jeong Yeon , Myeong Yun Chae , Hae Tak Jin , Hea Ran Suh , Kwang Hyeg Lee , Hyuk Koo Lee
IPC分类号： A61K31/4015 , A61K31/4422 , A61P9/10 , A61P9/12 , A61P43/00 , C07D207/28 , C07D211/90 , C07D211/86
CPC分类号： C07D211/90
摘要： Disclosed are a novel organic acid salt of amlodipine, its preparation method, and a pharmaceutical composition containing the same as a therapeutically active ingredient.
摘要翻译： 公开了一种新型的氨氯地平有机酸盐及其制备方法和含有其作为治疗活性成分的药物组合物。
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