发明授权
- 专利标题: Sulfonamide compounds and pharmaceutical use thereof
- 专利标题(中): 磺酰胺化合物及其药物用途
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申请号: US10047093申请日: 2002-01-17
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公开(公告)号: US06911469B2公开(公告)日: 2005-06-28
- 发明人: Hiroshi Kayakiri , Yoshito Abe , Hitoshi Hamashima , Hitoshi Sawada , Tsuyoshi Mizutani , Teruo Oku , Noritsugu Yamasaki , Osamu Onomura , Masahiro Nishikawa , Takahiro Hiramura , Takafumi Imoto
- 申请人: Hiroshi Kayakiri , Yoshito Abe , Hitoshi Hamashima , Hitoshi Sawada , Tsuyoshi Mizutani , Teruo Oku , Noritsugu Yamasaki , Osamu Onomura , Masahiro Nishikawa , Takahiro Hiramura , Takafumi Imoto
- 申请人地址: JP Osaka
- 专利权人: Fujisawa Pharmaceutical Co., Ltd.
- 当前专利权人: Fujisawa Pharmaceutical Co., Ltd.
- 当前专利权人地址: JP Osaka
- 代理机构: Oblon, Spivak, McClelland, Maier & Neustadt, P.C.
- 优先权: JP9/208295 19970627; JP10/114718 19980424
- 主分类号: G06Q50/10
- IPC分类号: G06Q50/10 ; A61K20060101 ; A61K31/381 ; A63B69/36 ; C07D20060101 ; C07D215/48 ; C07D231/56 ; C07D239/96 ; C07D241/52 ; C07D249/18 ; C07D307/79 ; C07D333/54 ; C07D333/56 ; C07D333/62 ; C07D405/12 ; C07D409/12 ; C07D471/04 ; C07D487/04 ; C07D495/04 ; C07F20060101 ; A61K31/34
摘要:
A sulfonamide compound of the formula (I): R1—SO2NHCO—A—X—R2 (I) wherein R1 is alky, alkenyl, alkynyl and the like; A is an optionally substitutedheteropolycyclic group except benzimidazolyl, indolyl, 4,7-dihydrobenzimidazolyland 2,3-dihydrobenzoxazinyl; X is alkylene, oxa, oxa(lower)alkylene and the like; and R2 is optionally substituted aryl, substituted biphenylyl and the like, a salt thereof and a pharmaceutical composition comprising the same. The sulfonamide compound is effective for the diseases treatable based on their blood sugar level-depressing activity, cGMP-PDE (especially PDE-V)-inhibiting activity, smooth muscle relaxing activity, bronchodilating activity, vasodilating activity, smooth muscle cell suppressing activity, and antiallergic activity.
公开/授权文献
- US06787565B2 Sulfonamide compounds and pharmaceutical use thereof 公开/授权日:2004-09-07