Invention Grant
- Patent Title: Luminescent method of detecting soluble guanylate cyclase
- Patent Title (中): 检测可溶性鸟苷酸环化酶的发光方法
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Application No.: US10268533Application Date: 2002-10-10
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Publication No.: US06913898B2Publication Date: 2005-07-05
- Inventor: Ursula Schindler , Hartmut Strobel , Peter Schindler , Alexander Muelsch
- Applicant: Ursula Schindler , Hartmut Strobel , Peter Schindler , Alexander Muelsch
- Applicant Address: DE Frankfurt
- Assignee: Aventis Pharma Deutschland GmbH
- Current Assignee: Aventis Pharma Deutschland GmbH
- Current Assignee Address: DE Frankfurt
- Priority: DE19944226 19990915
- Main IPC: G01N33/50
- IPC: G01N33/50 ; C12Q1/32 ; C12Q1/527 ; C12Q1/66 ; G01N21/78
Abstract:
The invention relates to methods for detecting a soluble guanylate cyclase whose heme iron is in the trivalent oxidation state, and to methods for finding chemical substances which stimulate the activity of a soluble guanylate cyclase when the heme iron of at least part of this soluble guanylate cyclase is oxidized to the trivalent state and also to diagnostic aids or kits for detecting a soluble guanylate cyclase with trivalent heme iron. Further, the invention relates methods for detecting a soluble guanylate cyclase lacking a heme group, and to methods for finding chemical substances which stimulate the activity of a soluble guanylate cyclase lacking a heme group.
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