Invention Grant
US06916603B2 Methods of using agents that modulate bone formation and inhibit adipogenesis
失效
使用调节骨形成和抑制脂肪形成的药剂的方法
- Patent Title: Methods of using agents that modulate bone formation and inhibit adipogenesis
- Patent Title (中): 使用调节骨形成和抑制脂肪形成的药剂的方法
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Application No.: US09939709Application Date: 2001-08-28
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Publication No.: US06916603B2Publication Date: 2005-07-12
- Inventor: Roland E. Baron , Natalie Sims , Georgios Sabatakos , Eric Nestler , Jingshan Chen , Max Kelz
- Applicant: Roland E. Baron , Natalie Sims , Georgios Sabatakos , Eric Nestler , Jingshan Chen , Max Kelz
- Applicant Address: US CT New Haven
- Assignee: Yale University
- Current Assignee: Yale University
- Current Assignee Address: US CT New Haven
- Agency: Morgan, Lewis & Bockius LLP
- Main IPC: G01N33/48
- IPC: G01N33/48 ; A01K67/027 ; A61K31/00 ; A61K45/00 ; A61K48/00 ; A61P19/08 ; A61P19/10 ; A61P43/00 ; C07H21/04 ; C12N5/06 ; C12N15/09 ; C12N15/63 ; C12N15/74 ; C12Q1/00 ; C12Q1/02 ; C12Q1/68 ; G01N1/30 ; G01N33/00 ; G01N33/15 ; G01N33/50 ; G01N33/53 ; G01N33/566 ; G01N33/68
Abstract:
The present invention is based on the discovery that overexpression of ΔFosB leads to bone formation and that ΔFosB expression inhibits adipogenesis. The present invention provides methods of identifying agents that modulate bone formation and adipogenesis. Moreover, the present invention provides methods for identifying genes that are modulated by ΔFosB and that modulates ΔFosB, osteogenesis, and adipogenesis.
Public/Granted literature
- US20020077273A1 Methods of using agents that modulate bone formation and inhibit adipogenesis Public/Granted day:2002-06-20
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