发明授权
- 专利标题： Methods and compositions for enhancing the delivery of a nucleic acid to a cell
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申请号： US09851327申请日： 2001-05-09
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公开(公告)号： US06919208B2公开(公告)日： 2005-07-19
- 发明人: Robert J. Levy , Peter L. Jones , Quanyi Li
- 申请人： Robert J. Levy , Peter L. Jones , Quanyi Li
- 申请人地址： US PA Philadelphia
- 专利权人： The Children's Hospital of Philadelphia
- 当前专利权人： The Children's Hospital of Philadelphia
- 当前专利权人地址： US PA Philadelphia
- 代理机构： Dann, Dorfman, Herrell and Skillman
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K31/7088 ; A61K38/00 ; A61K48/00 ; A61P43/00 ; C12N15/87 ; C12N15/63 ; C12N15/88 ; C12Q1/68
摘要：
The present invention relates to methods and compositions useful for enhancing the efficiency of delivery of a nucleic acid to a cell. Preferably the cell is a mammalian cell. The method comprises providing to a cell an agent capable of enhancing the cytoskeletal permissiveness of the cell for transfection. The method also comprises providing to the cell a nucleic acid delivery system for the transfection of the cell, whereby the efficiency of delivery of a nucleic acid to the cell is enhanced. Compositions and kits for enhancing the efficiency of delivery of a nucleic acid to a cell are also included