发明授权
- 专利标题： Sustained release pharmaceutical compositions
- 专利标题（中）： 持续释放药物组合物
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申请号： US09582404申请日： 1998-12-25
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公开(公告)号： US06919372B1公开(公告)日： 2005-07-19
- 发明人: Noboru Yamashita , Akira Takagi , Masataka Katsuma , Katsumi Saito , Yuuki Takaishi , Tatsuo Yasuda , Yutaka Takahashi , Mitsuo Mitomi , Michio Hara
- 申请人： Noboru Yamashita , Akira Takagi , Masataka Katsuma , Katsumi Saito , Yuuki Takaishi , Tatsuo Yasuda , Yutaka Takahashi , Mitsuo Mitomi , Michio Hara
- 申请人地址： JP Tokyo
- 专利权人： Yamanouchi Pharmaceutical Co., Ltd.
- 当前专利权人： Yamanouchi Pharmaceutical Co., Ltd.
- 当前专利权人地址： JP Tokyo
- 代理机构： Townsend and Townsend and Crew LLP
- 优先权： JP97360265 19971226
- 国际申请： PCT/JP98/05915 WO 19981225
- 国际公布： WO99/33490 WO 19990708
- 主分类号： A61K9/00
- IPC分类号： A61K9/00 ; A61K9/06 ; A61K31/557 ; A61K31/5575 ; A61K31/5585 ; A61K47/10 ; A61K47/12 ; A61K47/14 ; A61K47/18 ; A61K47/20 ; A61K47/36 ; A61K47/42 ; A61K47/44 ; A01N43/08 ; A61K31/34
摘要：
The present invention relates to sustained-release pharmaceutical compositions for ionic pharmaceutically active substances containing ionic compounds having opposite charges to those of ionic prostanoic acid derivatives and increasing hydrophobicity of the active substances. More specifically, the invention relates to sustained-release pharmaceutical compositions comprising the ionic prostanoic acid derivatives and the ionic compounds having opposite charges to those of the prostanoic acid derivatives and increasing hydrophobicity of these derivatives that contain hydrophobic groups in the molecule thereof.The pharmaceutical composition of the invention can exhibit excellent sustained release effect of the ionic prostanoic acid derivatives, irrespective of water solubility possessed by the ionic prostanoic acid derivatives.