发明授权
- 专利标题： Heteroarylalkanoic acids as integrin receptor antagonists
- 专利标题（中）： 杂芳基链烷酸作为整联蛋白受体拮抗剂
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申请号： US09881913申请日： 2001-06-15
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公开(公告)号： US06933304B2公开(公告)日： 2005-08-23
- 发明人: Srinivasan Raj Nagarajan , Ish Kumar Khanna , Michael B. Tollefson , Scott B. Mohler , Barbara Chen , Mark Russell , Balekudru Devadas , Thomas D. Penning , Lori A. Schretzman , Dale P. Spangler , Mark Laurence Boys , Nizal Samuel Chandrakumar , Hung-Fun Lu
- 申请人： Srinivasan Raj Nagarajan , Ish Kumar Khanna , Michael B. Tollefson , Scott B. Mohler , Barbara Chen , Mark Russell , Balekudru Devadas , Thomas D. Penning , Lori A. Schretzman , Dale P. Spangler , Mark Laurence Boys , Nizal Samuel Chandrakumar , Hung-Fun Lu
- 申请人地址： US MO Chesterfield
- 专利权人： Pharmacia Corporation
- 当前专利权人： Pharmacia Corporation
- 当前专利权人地址： US MO Chesterfield
- 代理机构： Harness, Dickey & Pierce
- 主分类号： A61K31/4245
- IPC分类号： A61K31/4245 ; A61K31/4375 ; A61K31/4439 ; A61K31/444 ; A61K31/4545 ; A61K31/4709 ; A61K31/496 ; A61K31/5383 ; A61P3/14 ; A61P9/00 ; A61P9/08 ; A61P9/10 ; A61P19/02 ; A61P19/10 ; A61P21/00 ; A61P27/02 ; A61P35/00 ; A61P43/00 ; C07D213/74 ; C07D231/38 ; C07D233/60 ; C07D233/88 ; C07D405/12 ; C07D413/06 ; C07D413/12 ; C07D413/14 ; C07D417/12 ; C07D471/04 ; C07D498/04
摘要：
The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively antagonizing the αVβ3 and/or the αVβ5 integrin without significantly antagonizing the IIb/IIIa or αVβ6 integrin.