发明授权
- 专利标题: Autoinducer molecule
- 专利标题(中): 自动诱导分子
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申请号: US09541873申请日: 2000-04-03
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公开(公告)号: US06936447B1公开(公告)日: 2005-08-30
- 发明人: James P. Pearson , Kendall M. Gray , Luciano Passador , Kenneth D. Tucker , Anatol Eberhard , Barbara H. Iglewski , Everett P. Greenberg
- 申请人: James P. Pearson , Kendall M. Gray , Luciano Passador , Kenneth D. Tucker , Anatol Eberhard , Barbara H. Iglewski , Everett P. Greenberg
- 申请人地址: US IA Iowa City US NY Rochester US NY Ithaca
- 专利权人: University of Iowa Research Foundation,University of Rochester,Ithaca College
- 当前专利权人: University of Iowa Research Foundation,University of Rochester,Ithaca College
- 当前专利权人地址: US IA Iowa City US NY Rochester US NY Ithaca
- 代理机构: Lahive & Cockfield, LLP
- 代理商 DeAnn F. Smith, Esq.; Elizabeth A. Hanley, Esq.
- 主分类号: A61K31/366
- IPC分类号: A61K31/366 ; A61K31/381 ; A61K31/382 ; A61K31/4015 ; C12N1/00 ; C12N1/20 ; C12N1/38 ; C12N9/00
摘要:
Autoinducer molecules, e.g., N-(3-oxododecanoyl)homoserine lactone, for Pseudomonas aeruginosa are described. The molecules regulate gene expression in the bacterium. Therapeutic compositions and therapeutic methods involving analogs and/or inhibitors of the autoinducer molecules also are described. The molecules are useful for treating or preventing infection by Pseudomonas aeruginosa.