发明授权
- 专利标题: Pyrimidine matrix metalloproteinase inhibitors
- 专利标题(中): 嘧啶基质金属蛋白酶抑制剂
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申请号: US10075909申请日: 2002-02-13
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公开(公告)号: US06936616B2公开(公告)日: 2005-08-30
- 发明人: Nicole Chantel Barvian , William Chester Patt
- 申请人: Nicole Chantel Barvian , William Chester Patt
- 申请人地址: US NJ Morris Plains
- 专利权人: Warner-Lambert Company
- 当前专利权人: Warner-Lambert Company
- 当前专利权人地址: US NJ Morris Plains
- 代理商 Claude F. Purchase, Jr.; Todd M. Grissey; Charles W. Ashbrook
- 主分类号: A61K31/505
- IPC分类号: A61K31/505 ; A61K31/506 ; A61K31/513 ; A61K31/5377 ; A61K31/541 ; A61P9/04 ; A61P19/02 ; A61P29/00 ; A61P35/00 ; A61P43/00 ; C07D239/28 ; C07D401/12 ; C07D405/12 ; C07D405/14 ; C07D409/12 ; C07D413/14 ; C07D417/12 ; C07D417/14 ; C07D413/02 ; C07D417/02 ; C07D43/02
摘要:
Selective MMP-13 inhibitors are pyrimidine derivatives of the formula or a pharmaceutically acceptable salt thereof, wherein: R2 is hydrogen, halo, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, NO2, NR4R5, CN, or CF3; E is independently O or S; A and B independently are OR4 or NR4R5; R4 and R5 independently are H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, (CH2)n aryl, (CH2)n cycloalkyl, (CH2)n heteroaryl, or R4 and R5 when taken together with the nitrogen to which they are attached complete a 3- to 8-membered ring containing carbon atoms and optionally containing a heteroatom selected from O, S, or NH, and optionally substituted or unsubstituted; n is an integer of from 0 to 6.
公开/授权文献
- US20020151555A1 Pyrimidine matrix metalloproteinase inhibitors 公开/授权日:2002-10-17