利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

18 条记录 (耗时 0.027 秒)

    Biphenyl sulfonamides useful as matrix metalloproteinase inhibitors
    7.
    发明授权
    Biphenyl sulfonamides useful as matrix metalloproteinase inhibitors 失效
    联苯磺酰胺可用作基质金属蛋白酶抑制剂

    公开(公告)号：US06686355B2

    公开(公告)日：2004-02-03

    申请号：US10074667

    申请日：2002-02-13

    申请人： Nicole Chantel Barvian ,  Patrick Michael O'Brien ,  William Chester Patt ,  Drago Robert Sliskovic

    发明人： Nicole Chantel Barvian ,  Patrick Michael O'Brien ,  William Chester Patt ,  Drago Robert Sliskovic

    IPC分类号： C07D27912

    CPC分类号： C07D417/12 ,  C07D279/12

    摘要： Inhibitors of MMP enzymes are cyclic sulfonamides of Formula I or a pharmaceutically acceptable salt thereof, and cyclic sulfonamides of Formula III or a pharmaceutically acceptable salt thereof, wherein R1 and R2 include hydrogen, alkyl, and substituted alkyl; R3 and R4 include hydrogen, halo, and alkyl; X is OH or NHOH: Z is (CH2)n: and Y is S, SO or SO2. The compounds of Formulas I and III are useful for the treatment of diseases mediated by an MMP enzyme, including cancer, osteoarthritis, rheumatoid arthritis, heart failure, and inflammation.

    摘要翻译： MMP酶的抑制剂是式I的环状磺酰胺或其药学上可接受的盐，以及式III的环状磺酰胺或其药学上可接受的盐，其中R 1和R 2包括氢，烷基和取代的烷基; R 3和R 4包括氢，卤素和烷基; X是OH或NHOH：Z是（CH 2）n：Y是S，SO或SO 2。 式I和III的化合物可用于治疗由MMP酶介导的疾病，包括癌症，骨关节炎，类风湿性关节炎，心力衰竭和炎症。

    Nonpeptide endothelin antagonists with increased water solubility
    8.
    发明授权
    Nonpeptide endothelin antagonists with increased water solubility 失效
    具有增加的水溶性的非肽内皮素拮抗剂

    公开(公告)号：US06297274B1

    公开(公告)日：2001-10-02

    申请号：US09117667

    申请日：1998-08-04

    申请人： Xue-Min Cheng ,  Annette Marian Doherty ,  William Chester Patt ,  Joseph Thomas Repine

    发明人： Xue-Min Cheng ,  Annette Marian Doherty ,  William Chester Patt ,  Joseph Thomas Repine

    IPC分类号： A61K3134

    CPC分类号： C07D407/04 ,  C07D307/60

    摘要： Novel nonpeptide endothelin I antagonists of Formula are described wherein R1 is unsubstituted or substituted cycloalkyl, phenyl, naphthyl or heteroaryl, R2 is unsubstituted or substituted alkyl, aryl or heteroaryl, R3 is unsubstituted or substituted alkyl, cycloalkyl, aryl or heteroayl, and R1 and/or R2 and/or R3 are independently substituted by a total of from 1 to 4 substituents which enhance aqueous solubility with the proviso that when R2 is alkyl and is substituted, the substituent is not oxygen at the &agr;-position of the furanone ring. Further described are methods for the preparation and pharmaceutical compositions of compounds of Formula I, which are useful in treating atherosclerosis, restenosis, Raynaud's phenomenon, mild or severe congestive heart failure, cerebral ischemia, cerebral infarction, embolic stroke, cerebral vasospasm, glaucoma, subarachnoid hemorrhage, hemorrhagic stroke, diabetes, gastric ulceration and mucosal damage, ischemic bowel disease, Chrohn's disease, male penile erectile dysfunction, essential or malignant hypertension, pulmonary hypertension, pulmonary hypertension after bypass, cancer, especially malignant hemangioendothelioma or prostate cancer, myocardial infarction or ischemia, acute or chronic renal failure, renal ischemia, radiocontrast-induced nephrotoxcity, endotoxic, septic hemorrhagic shock, angina, preeclampsia, asthma, arrhythmias, benign prostatic hyperplasia, and elevated levels of endothelin.

    摘要翻译： 苯基，萘基或杂芳基，R2为未取代或取代的烷基，芳基或杂芳基，R3为未取代或取代的烷基，环烷基，芳基或杂芳基，R1和/ 或R 2和/或R 3独立地被总共1至4个增强水溶性的取代基取代，条件是当R 2是烷基且被取代时，该取代基不是在呋喃酮环的α-位上的氧。 进一步描述了用于制备治疗动脉粥样硬化，再狭窄，雷诺现象，轻度或重度充血性心力衰竭，脑缺血，脑梗死，栓塞性中风，脑血管痉挛，青光眼，蛛网膜下腔出血 出血性，出血性中风，糖尿病，胃溃疡和粘膜损伤，缺血性肠病，克罗恩病，男性阴茎勃起功能障碍，基本或恶性高血压，肺动脉高压，旁路后肺动脉高压，癌症，特别是恶性血管内皮瘤或前列腺癌，心肌梗塞或 缺血，急性或慢性肾衰竭，肾缺血，放射性对照诱导的肾毒性，内毒素性，败血性出血性休克，心绞痛，先兆子痫，哮喘，心律失常，良性前列腺增生和内皮素水平升高。

    Small molecule biaryl compounds as inhibitors of endothelin converting enzyme
    9.
    发明授权
    Small molecule biaryl compounds as inhibitors of endothelin converting enzyme 失效
    小分子联芳基化合物作为内皮素转化酶的抑制剂

    公开(公告)号：US5891892A

    公开(公告)日：1999-04-06

    申请号：US949632

    申请日：1997-10-14

    申请人： Xue-Min Cheng ,  Mark Alan Massa ,  William Chester Patt

    发明人： Xue-Min Cheng ,  Mark Alan Massa ,  William Chester Patt

    IPC分类号： C07D417/04 ,  A61K31/44

    CPC分类号： C07D417/04

    摘要： Novel small molecular biaryl compounds as inhibitors of endothelin converting enzyme are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin, acute and chronic renal failure, hypertension, myocardial infarction, myocardial ischemia, cerebral vasospasm, cerebral ischemia, cerebral infarction, cirrhosis, septic shock, congestive heart failure, endotoxic shock, subarachnoid hemorrhage, arrhythmias, asthma, preeclampsia, atherosclerotic disorders including Raynaud's disease and restenosis, angina, cancer, pulmonary hypertension, ischemic disease, gastric mucosal damage, hemorrhagic shock, ischemic bowel disease, stroke, benign prosthatic hyperplasia (BPH), and diabetes.

    摘要翻译： 描述了新型小分子联芳基化合物作为内皮素转化酶的抑制剂，以及其制备方法及其药物组合物，其可用于治疗高水平的内皮素，急性和慢性肾衰竭，高血压，心肌梗死，心肌 缺血，脑血管痉挛，脑缺血，脑梗塞，肝硬化，败血性休克，充血性心力衰竭，内毒素性休克，蛛网膜下腔出血，心律失常，哮喘，先兆子痫，动脉粥样硬化疾病包括雷诺氏病和再狭窄，心绞痛，癌症，肺动脉高压，缺血性疾病， 胃粘膜损伤，出血性休克，缺血性肠病，中风，良性前列腺增生（BPH）和糖尿病。