发明授权
- 专利标题： Compositions and methods for regulating bacterial pathogenesis
- 专利标题（中）： 用于调节细菌发病机理的组合物和方法
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申请号： US09961452申请日： 2001-09-21
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公开(公告)号： US06942986B2公开(公告)日： 2005-09-13
- 发明人: Bonnie L. Bassler , Michael G. Surette
- 申请人： Bonnie L. Bassler , Michael G. Surette
- 申请人地址： US NJ Princeton CA Alberta
- 专利权人： Princeton University,University Technologies International
- 当前专利权人： Princeton University,University Technologies International
- 当前专利权人地址： US NJ Princeton CA Alberta
- 代理机构： Mathews, Collins, Shept & McKay, P.A.
- 主分类号： A61K31/00
- IPC分类号： A61K31/00 ; A61K38/00 ; C07K14/195 ; C12N1/21 ; C12Q1/18 ; C12Q1/68 ; G01N33/554
摘要：
The production of a purified extracellular bacterial signal called autoinducer-2 is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. Autoinducer-2 stimulates LuxQ luminescence genes, and is believed also to stimulate a variety of pathogenesis related genes in the bacterial species that produce it. A new class of bacterial genes is involved in the biosynthesis of autoinducer-2.
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