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    Compositions and methods for regulating bacterial pathogenesis
    2.
    发明授权
    Compositions and methods for regulating bacterial pathogenesis 有权
    用于调节细菌发病机理的组合物和方法

    公开(公告)号：US07326542B2

    公开(公告)日：2008-02-05

    申请号：US10387345

    申请日：2003-03-10

    申请人： Bonnie L. Bassler ,  Michael G. Surette

    发明人： Bonnie L. Bassler ,  Michael G. Surette

    IPC分类号： A61K38/17

    CPC分类号： A61K31/00 ,  A61K38/00 ,  C07K14/195 ,  C12Q1/18 ,  C12Q1/68 ,  C12Q1/6897 ,  Y02A50/401 ,  Y02A50/471 ,  Y02A50/57

    摘要： The production of a purified extracellular bacterial signal called autoinducer-2 is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. Autoinducer-2 stimulates LuxQ luminescence genes, and is believed also to stimulate a variety of pathogenesis related genes in the bacterial species that produce it. A new class of bacterial genes is involved in the biosynthesis of autoinducer-2.

    摘要翻译： 称为自体诱导剂-2的纯化的细胞外细菌信号的产生由与宿主生物体中的自由存活存在转移到定植或致病性存在相关的环境条件的变化来调节。 自动诱导剂-2刺激LuxQ发光基因，并且还被认为刺激产生它的细菌种类中的各种发病相关基因。 一类新的细菌基因参与了自动诱导剂-2的生物合成。

    Compositions and methods for regulating bacterial pathogenesis
    5.
    发明授权
    Compositions and methods for regulating bacterial pathogenesis 有权
    用于调节细菌发病机理的组合物和方法

    公开(公告)号：US06720415B2

    公开(公告)日：2004-04-13

    申请号：US09453976

    申请日：1999-12-02

    申请人： Bonnie L. Bassler ,  Michael G. Surette

    发明人： Bonnie L. Bassler ,  Michael G. Surette

    IPC分类号： C07H2104

    CPC分类号： C12Q1/18 ,  A61K31/00 ,  A61K38/00 ,  C07K14/195 ,  C12Q1/68 ,  Y02A50/401 ,  Y02A50/47 ,  Y02A50/471 ,  Y02A50/57 ,  Y10S435/909 ,  Y10S530/806 ,  Y10S530/808

    摘要： This invention provides a purified extracellular bacterial autoinducer-2 signaling molecule, the production of which is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. The signaling molecule stimulates LuxQ luminescence genes, and is believed also to stimulate a variety of pathogenesis related genes in the bacterial species that produce it. This invention also provides is a new class of bacterial genes involved in the biosynthesis of the signaling molecule.

    摘要翻译： 本发明提供了一种纯化的细胞外细菌自体诱导剂-2信号分子，其生产受到与自由存活存在转移至宿主生物体内定植或致病性存在相关的环境条件变化的调节。 信号分子刺激LuxQ发光基因，并且还被认为是刺激产生它的细菌种中的各种发病相关基因。 本发明还提供了涉及信号分子生物合成的新类型的细菌基因。