发明授权
- 专利标题： Cyclic diamine compounds and medicine containing the same
- 专利标题（中）： 环状二胺化合物和含有相同的药物
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申请号： US10371234申请日： 2003-02-20
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公开(公告)号： US06969711B2公开(公告)日： 2005-11-29
- 发明人: Kimiyuki Shibuya , Katsumi Kawamine , Yukihiro Sato , Toru Miura , Chiyoka Ozaki , Toshiyuki Edano , Mitsuteru Hirata , Tadaaki Ohgiya
- 申请人： Kimiyuki Shibuya , Katsumi Kawamine , Yukihiro Sato , Toru Miura , Chiyoka Ozaki , Toshiyuki Edano , Mitsuteru Hirata , Tadaaki Ohgiya
- 申请人地址： JP Aichi
- 专利权人： Kowa Company, Ltd.
- 当前专利权人： Kowa Company, Ltd.
- 当前专利权人地址： JP Aichi
- 代理机构： Edwards & Angell, LLP
- 代理商 Peter F. Corless; John B. Alexander
- 优先权： JP9-149892 19970526
- 主分类号： C07D235/28
- IPC分类号： C07D235/28 ; C07D263/58 ; C07D277/74 ; C07D401/12 ; C07D413/12 ; C07D417/12 ; C07D498/04 ; C07F9/6509 ; C07F9/6558 ; C07D403/12 ; A61K31/454 ; A61P9/10
摘要：
The present invention offers novel cyclic diamine compounds and a pharmaceutical composition containing the same.The present invention relates to a compound represented by the formula (I) or salt(s) or solvate(s) thereof. (In the formula, is an optionally substituted divalent residue of benzene, pyridine, cyclohexane or naphthalene or is a vinylene group where Ar is an optionally substituted aryl group; X is —NH—, oxygen atom or sulfur atom; Y is —NR1—, oxygen atom, sulfur atom, sulfoxide or sulfone; Z is a single bond or —NR2—; R1 is hydrogen atom, optionally substituted lower alkyl group, optionally substituted aryl group or optionally substituted silyl lower alkyl group; R2 is hydrogen atom, optionally substituted lower alkyl group, optionally substituted aryl group or optionally substituted silyl lower alkyl group; l is an integer of from 0 to 15; m is an integer of 2 or 3; and n is an integer of from 0 to 3). The compound of the present invention is useful as a pharmaceutical composition, particuarly as an inhibitor of acyl coenzyme A cholesterol acyltransferase (ACAT).