发明授权
- 专利标题： Gene therapy by cell specific targeting
- 专利标题（中）： 通过细胞特异性靶向进行基因治疗
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申请号： US08922240申请日： 1997-08-27
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公开(公告)号： US06982082B1公开(公告)日： 2006-01-03
- 发明人: Stuart L. Schreiber , Peter J. Belshaw , Gerald Crabtree
- 申请人： Stuart L. Schreiber , Peter J. Belshaw , Gerald Crabtree
- 申请人地址： US MA Cambridge US CA Stanford
- 专利权人： President and Fellows of Harvard College,Board of Trustees of the Leland Stanford Junior University
- 当前专利权人： President and Fellows of Harvard College,Board of Trustees of the Leland Stanford Junior University
- 当前专利权人地址： US MA Cambridge US CA Stanford
- 代理机构： Fish & Neave IP Group of Ropes & Gray, LLP
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C12N5/00 ; C12N15/00 ; C12N15/63 ; C12N15/74
摘要：
This invention is directed to a modified cyclosporin A and to a modified, genetically engineered version of its receptor, cyclophilin. This invention is further directed to a method for treating host versus graft disease following blood marrow transplantation by transfecting stem cells so that after introduction into a patient the stem cells will express the modified cyclophilin, and, as necessary, administer the modified cyclosporin A to the patient.