- 专利标题： Substituted 11-phenyl-dibenzazepine compounds useful for the treatment or prevention of diseases characterized by abnormal cell proliferation
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申请号： US10013308申请日： 2001-12-07
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公开(公告)号： US06992079B2公开(公告)日： 2006-01-31
- 发明人: Carlo Brugnara , Jose Halperin , Rudolf Fluckiger , Emile M. Bellott, Jr. , Richard John Lombardy , John J. Clifford , Ying-Duo Gao , Reem M. Haidar , Eugene W. Kelleher , Adel M. Moussa , Yesh P. Sachdeva , Minghua Sun , Heather N. Taft , Michael H. Zeldin
- 申请人： Carlo Brugnara , Jose Halperin , Rudolf Fluckiger , Emile M. Bellott, Jr. , Richard John Lombardy , John J. Clifford , Ying-Duo Gao , Reem M. Haidar , Eugene W. Kelleher , Adel M. Moussa , Yesh P. Sachdeva , Minghua Sun , Heather N. Taft , Michael H. Zeldin
- 申请人地址： US MA Cambridge US MA Boston unknown Toronto
- 专利权人： President Fellows of Harvard College,Children's Medical Center Corporation,NuChem Pharmaceuticals Inc.
- 当前专利权人： President Fellows of Harvard College,Children's Medical Center Corporation,NuChem Pharmaceuticals Inc.
- 当前专利权人地址： US MA Cambridge US MA Boston unknown Toronto
- 代理机构： Fish & Richardson P.C.
- 主分类号： A61K31/55
- IPC分类号： A61K31/55 ; C07D233/18
摘要：
The present invention provides substituted 11-phenyl-dibenzazepine compounds which are specific, potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a therapeutic approach towards the treatment or prevention of diseases characterized by abnormal cell proliferation, such as cancer.
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