发明授权
- 专利标题： Apparatus and method for screening, olfactory mucosa stimulating compound found by the screening method, and therapeutic apparatus and electrode section for measurement
- 专利标题（中）： 筛选方法，筛选方法发现的嗅觉粘膜刺激化合物，以及用于测量的治疗仪和电极部分
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申请号： US10070170申请日： 2001-06-25
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公开(公告)号： US06994671B2公开(公告)日： 2006-02-07
- 发明人: Hiroaki Oka , Ryuta Ogawa , Tetsuo Yukimasa
- 申请人： Hiroaki Oka , Ryuta Ogawa , Tetsuo Yukimasa
- 申请人地址： JP Osaka
- 专利权人： Matsushita Electric Industrial Co., Ltd.
- 当前专利权人： Matsushita Electric Industrial Co., Ltd.
- 当前专利权人地址： JP Osaka
- 代理机构： Snell & Wilmer, LLP
- 优先权： JP2000-204411 20000705
- 国际申请： PCT/JP01/05426 WO 20010625
- 国际公布： WO02/02009 WO 20020110
- 主分类号： A61B5/08
- IPC分类号： A61B5/08 ; A61B5/00 ; A61N1/30 ; A61M31/00
摘要：
A method and apparatus for readily and reliably screening olfactory mucosa stimulating compounds are provided. An olfactory mucosa stimulating compound is sprayed through an atomizing nozzle 33 to an olfactory mucosa of a rat fixed in a test animal fixing device 32. A measuring electrode portion 10 is implanted in an olfactory bulb of the rat for measuring an electrical signal generated in the olfactory bulb. Efficacy of the olfactory mucosa stimulating compound is determined based on a correlation between an electrical signal measured by the measuring electrode portion 10 when the olfactory mucosa stimulating compound is sprayed on the olfactory mucosa of the rat and a physiological response induced in the rat.
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