A valve gear with a cylinder suspending mechanism of an internal combustion engine, whose entire valve gear mechanism is downsized by efficiently arranging the configuration of the valve gear including the cylinder suspending mechanism. A low-speed drive rocker arm and a high-speed drive rocker arm are disposed in front and at the rear of an intake driven rocker arm so that pistons of low-speed and high-speed cylinder portions arranged side by side in the intake driven rocker arm may be pressed by operating operation arm portions extending from the respective drive rocker arms, to thereby arrange the low-speed and high-speed cylinder portions and the low-speed and high-speed drive rocker arms around the intake driven rocker arm to gather in one place.