发明授权
- 专利标题： Methods of identifying agents that mediate polypeptide aggregation
- 专利标题（中）： 鉴定介导多肽聚集的试剂的方法
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申请号： US10470765申请日： 2002-02-11
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公开(公告)号： US07015012B2公开(公告)日： 2006-03-21
- 发明人: David E. Housman , Aleksey G. Kazantsev
- 申请人： David E. Housman , Aleksey G. Kazantsev
- 申请人地址： US MA Cambridge
- 专利权人： Massachusetts Institute of Technology
- 当前专利权人： Massachusetts Institute of Technology
- 当前专利权人地址： US MA Cambridge
- 代理机构： Fish & Richardson P.C.
- 优先权： WOPCT/US02/04059 20020211
- 国际申请： PCT/US02/04059 WO 20020211
- 国际公布： WO02/064618 WO 20020822
- 主分类号： C12Q1/02
- IPC分类号： C12Q1/02
摘要：
The present invention is based, in part, on the discovery of methods for identifying compounds that mediate (by promoting or inhibiting) protein-protein interaction (e.g., aggregation, dimerization, or other physiologically significant association). Compounds that mediate such interaction, which are also within the scope of the invention, can be used to treat Alzheimer's disease, disorders associated with expanded CAG repeats (such as Huntington's disease), and disorders in which polyglutamine-containing transcription factors or coactivators are undesirably active (e.g., disorders associated with homodimerization of jun or hexamerization of p53.
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