发明授权
US07018619B2 Delivery of alprazolam, estazolam midazolam or triazolam through an inhalation route
有权
通过吸入途径输送阿普唑仑，艾唑仑唑咪唑安定或三唑仑
- 专利标题： Delivery of alprazolam, estazolam midazolam or triazolam through an inhalation route
- 专利标题（中）： 通过吸入途径输送阿普唑仑，艾唑仑唑咪唑安定或三唑仑
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申请号： US10735495申请日： 2003-12-12
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公开(公告)号： US07018619B2公开(公告)日： 2006-03-28
- 发明人: Joshua D. Rabinowitz , Alejandro C. Zaffaroni
- 申请人： Joshua D. Rabinowitz , Alejandro C. Zaffaroni
- 申请人地址： US CA Palo Alto
- 专利权人： Alexza Pharmaceuticals, Inc.
- 当前专利权人： Alexza Pharmaceuticals, Inc.
- 当前专利权人地址： US CA Palo Alto
- 代理机构： Swanson & Bratschun, LLC
- 代理商 William L. Leschensky
- 主分类号： A61K9/12
- IPC分类号： A61K9/12 ; A61K9/14 ; A61K15/00
摘要：
The present invention relates to the delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route. Specifically, it relates to aerosols containing alprazolam, estazolam, midazolam or triazolam that are used in inhalation therapy. In a method aspect of the present invention, alprazolam, estazolam, midazolam or triazolam is administered to a patient through an inhalation route. The method comprises: a) heating a composition of alprazolam, estazolam, midazolam or triazolam, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles with less than 5% drug degradation products. In a kit aspect of the present invention, a kit for delivering alprazolam, estazolam, midazolam or triazolam through an inhalation route is provided which comprises: a) a thin coating of an alprazolam, estazolam, midazolam, or triazolam composition and b) a device for dispensing said thin coating as a condensation aerosol.
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