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1.发明授权Delivery of alprazolam, estazolam midazolam or triazolam through an inhalation route 有权通过吸入途径输送阿普唑仑，艾唑仑唑咪唑安定或三唑仑公开(公告)号：US07018619B2
公开(公告)日：2006-03-28
申请号：US10735495
申请日：2003-12-12
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/192 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , F24V30/00 , Y10S514/958
摘要： The present invention relates to the delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route. Specifically, it relates to aerosols containing alprazolam, estazolam, midazolam or triazolam that are used in inhalation therapy. In a method aspect of the present invention, alprazolam, estazolam, midazolam or triazolam is administered to a patient through an inhalation route. The method comprises: a) heating a composition of alprazolam, estazolam, midazolam or triazolam, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles with less than 5% drug degradation products. In a kit aspect of the present invention, a kit for delivering alprazolam, estazolam, midazolam or triazolam through an inhalation route is provided which comprises: a) a thin coating of an alprazolam, estazolam, midazolam, or triazolam composition and b) a device for dispensing said thin coating as a condensation aerosol.
摘要翻译： 本发明涉及通过吸入途径递送阿普唑仑，艾司唑仑，咪达唑仑或三唑仑。 具体来说，它涉及用于吸入治疗的含有阿普唑仑，艾司唑仑，咪达唑仑或三唑仑的气溶胶。 在本发明的方法方面，通过吸入途径向患者施用阿普唑仑，艾司唑仑，咪达唑仑或三唑仑。 该方法包括：a）加热阿普唑仑，咪达唑仑或三唑仑组合物以形成蒸气; 和b）允许蒸气冷却，由此形成包含具有小于5％药物降解产物的颗粒的凝结气溶胶。 在本发明的试剂盒方面，提供了一种用于通过吸入途径输送阿普唑仑，艾司唑仑，咪达唑仑或三唑仑的试剂盒，其包括：a）阿普唑仑，咪达唑仑或三唑仑组合物的薄涂层，和b） 用于分配所述薄涂层作为凝结气溶胶。
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2.发明授权Polyvinylpyrrolidone-iodide compositions and polyvinylpyrrolidone-iodide-iodine complexes prepared therefrom 失效聚乙烯吡咯烷酮碘化物组合物和由其制备的聚乙烯吡咯烷酮碘化物 - 碘络合物
公开(公告)号：US3898326A
公开(公告)日：1975-08-05
申请号：US36033873
申请日：1973-05-14
发明人： CANTOR ABRAHAM , WINICOV MURRAY W
IPC分类号： C07D207/267 , A43B3/12 , C11D1/00 , A61K15/00 , A01N11/00 , A61K17/00 , A61K19/00 , A61K21/00
摘要： A unique PVP-iodide solid solution is prepared by drying a solution of PVP and iodide wherein the PVP:I ratio is preferably in the range of about 2:1 to 6:1, which dried product may then be mechanically blended with elemental iodine at ambient temperature to rapidly form a stabilized PVP-iodide-iodine complex, characterized in that the resulting product comprises a single solid phase.
摘要翻译： 通过干燥PVP和碘化物溶液制备独特的PVP-碘固体溶液，其中PVP:I-比率优选在约2:1至6:1的范围内，然后将干燥的产物与 元素碘在环境温度下快速形成稳定的PVP-碘 - 碘络合物，其特征在于所得产物包含单个固相。
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公开(公告)号：US3767789A
公开(公告)日：1973-10-23
申请号：US3767789D
申请日：1971-06-21
发明人： RANKIN B
CPC分类号： A61K31/77 , A61K8/365 , A61K8/86 , A61K9/0031 , A61K9/006 , A61K9/0095 , A61K47/10 , A61Q11/00
摘要： A SYNTHETIC MUCUS IS APPLIED TO MUCUS MEMBRANES BY FORMING AN AQUEOUS SOLUTION OF ABOUT .05 TO 10 WEIGHT PERCENT OF A POLYTHLENE OXIDE HAVING A MOLECULAR WEIGHT OF AT LEAST ABOUT 100,000.
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公开(公告)号：US3482017A
公开(公告)日：1969-12-02
申请号：US3482017D
申请日：1969-01-21
申请人： CARLTON S NASH
发明人： NASH CARLTON S
CPC分类号： A23K50/70
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公开(公告)号：US3929990A
公开(公告)日：1975-12-30
申请号：US49532874
申请日：1974-08-07
申请人： MILLMASTER ONYX CORP
IPC分类号： A61K8/06 , A61K8/40 , A61K8/84 , A61Q17/00 , B01F17/00 , C02F1/50 , C08G73/02 , A01N9/20 , A01N9/24 , A61K15/00 , A61K17/00
CPC分类号： A61Q17/005 , A61K8/064 , A61K8/40 , A61K8/84 , A61K2800/524 , B01F17/0042 , C02F1/50 , C08G73/0213 , C08G73/0226 , Y10S514/943
摘要： Water-in-oil emulsions containing a polymeric quaternary ammonium compound prepared by the condensation of 1,4-dihalo-2butene and 1,4-bis-dimethylamino-2-butene as a biocidal agent, and wherein the emulsifying agent is an amine oxide.
摘要翻译： 含有通过1,4-二卤-2-丁烯和1,4-双 - 二甲基氨基-2-丁烯缩合制备的聚合季铵化合物作为杀生物剂的油包水乳液，其中乳化剂是 氧化胺。
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公开(公告)号：US3655882A
公开(公告)日：1972-04-11
申请号：US3655882D
申请日：1968-08-26
申请人： STALEY MFG CO A E
摘要： A STABLE, SUBSTANTIALLY ANHYDROUS, WATER-DISPERSIBLE DIETARY SUPPLEMENT FOR SUPPLYING SUPPLEMENTAL IRON ANTIBIOTICS AND VITAMINS TO NEWBORN PIGS WHICH COMPRISES A SUBSTANTIALLY ANHYDROUS, PREMIXED FORMULA INCLUDING AN IRON SALT SUCH AS FERRIC AMMONIUM CITRATE, AN ANTIBIOTIC SUCH AS NEOMYCIN SULFATE, A VITAMIN MINERAL SUPPLEMENT, AND A SUBSTANTIALLY ANHYDROUS DEXTROSE SWEETENER. THE COMPLETE PREMIXED FORMULA IS A SUBSTANTIALLY WATER-FREE MIXTURE HAVING AN EXCELLENT SHELF LIFE, BUT WHICH IS READILY DISPERSED IN THE NEWBORN PIG''S DRINKING WATER FOR VOLUNTARY CONSUMPTION IN AMOUNTS SUFFICIENT TO TREAT IRON DEFICIENCY ANEMIA, SUPPLEMENT VITAMIN REQUIREMENTS AND TO MINIMIZE SCOURS.
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公开(公告)号：US3584114A
公开(公告)日：1971-06-08
申请号：US3584114D
申请日：1968-05-22
申请人： HOFFMANN LA ROCHE
发明人： CAVALLI ARNOLD , DREKTER LEON
CPC分类号： A61K9/16 , A23P10/28 , A23P30/10 , A61K9/2013 , A61K9/2095 , Y10S514/904
摘要： THERE ARE DISCLOSED METHODS FOR PRODUCING FREE FLOWING, DIRECTLY COMPRESSIBLE COMPOSITIONS FROM POOR FLOWING POWDERS BY MIXING THE POOR FLOWING POWDERS INTO MELTED WAXY-LIKE EDIBLE MATERIALS SUCH AS STEARIC ACID, CARBOWAX, GLYCERYL MONOSTEARATE AND THE LIKE. THE THUS PRODUCED COMPOSITIONS CAN, IF DESIRED, BE COVERTED INTO TABLETS WITH EXCELLENT PROPERITIES BY DIRECT COMPRESSION.
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公开(公告)号：US3497589A
公开(公告)日：1970-02-24
申请号：US3497589D
申请日：1967-01-12
申请人： HOFFMANN LA ROCHE
CPC分类号： A23L33/15 , A23P10/30 , A23P10/43 , A23V2002/00 , A23V2250/7042 , A23V2200/22 , A23V2250/192 , A23V2250/182 , A23V2250/1876 , A23V2250/1628 , A23V2250/704 , A23V2250/156 , A23V2250/702 , A23V2250/5432 , A23V2250/628 , A23V2250/1592 , A23V2250/16 , A23V2250/1598
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公开(公告)号：US3453368A
公开(公告)日：1969-07-01
申请号：US3453368D
申请日：1966-01-13
申请人： HOFFMANN LA ROCHE
发明人： MAGID LOUIS
IPC分类号： A61K9/16 , A61K9/20 , A61K31/375 , A61K15/00 , A61K9/00
CPC分类号： A61K31/375 , A61K9/16 , A61K9/2004
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公开(公告)号：US3911114A
公开(公告)日：1975-10-07
申请号：US32662973
申请日：1973-01-26
申请人： ARIZONA FEEDS
发明人： CARDON BARTLEY P
CPC分类号： A61K45/06 , A23K20/163
摘要： Stressed ruminants are treated by directly introducing into the rumens thereof, as by drenching, an aqueous mixture of pregelatinized starch, vitamins and minerals. Other components of the mixture can include a gelling agent, propylene glycol, and chelated trace minerals.
摘要翻译： 通过将预胶化淀粉，维生素和矿物质的水性混合物直接引入其瘤胃来治疗受压的反刍动物。 混合物的其它组分可包括胶凝剂，丙二醇和螯合微量矿物质。
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