发明授权
- 专利标题： Methods for determining the acetylation level of a peptide based on sensitivity of the peptide to peptidase
- 专利标题（中）： 基于肽对肽酶的灵敏度测定肽的乙酰化水平的方法
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申请号： US10157382申请日： 2002-05-29
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公开(公告)号： US07033778B2公开(公告)日： 2006-04-25
- 发明人: Katsuyuki Tamai , Toshiaki Miyazaki , Emi Wada , Ayumi Tatsuzawa
- 申请人： Katsuyuki Tamai , Toshiaki Miyazaki , Emi Wada , Ayumi Tatsuzawa
- 申请人地址： JP Nagano
- 专利权人： Cyclex Co., Ltd.
- 当前专利权人： Cyclex Co., Ltd.
- 当前专利权人地址： JP Nagano
- 代理机构： Edwards & Angell, LLP
- 代理商 Peter F. Corless; Christine C. O'Day
- 优先权： JP11-338565 19991129
- 主分类号： C12Q1/37
- IPC分类号： C12Q1/37
摘要：
The acetylation level of a peptide is determined utilizing the fact that the changes in the acetylation level are reflected in the sensitivity of the substrate peptide to a peptidase. This method can be used for measuring activities of deacetylase and acetylase, and also enables screening for substances that influence the activity of these enzymes. The deacetylase activity can be measured by a simple procedure according to the present invention.
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