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发明授权
US07056954B2 Means for the modulation of processes mediated by retinoid receptors and compounds useful therefor 失效
用于调节由类视黄醇受体介导的过程和对其有用的化合物的方法

Means for the modulation of processes mediated by retinoid receptors and compounds useful therefor
摘要：
In accordance with the present invention, there are provided methods to modulate processes mediated by retinoid receptors, employing high affinity, high specificity ligands for such receptors. In one aspect of the present invention, there are provided ligands which are more selective for the retinoid X receptor than is retinoic acid (i.e., rexoids). In another aspect of the present invention, alternative ligands (other than retinoic acid) have been discovered which are capable of inducing retinoic acid receptor mediated processes. In yet another aspect, methods have been developed for the preparation of such retinoid receptor ligands from readily available compounds.
摘要（中）：

根据本发明，提供了调节由类视黄醇受体介导的过程的方法，其使用这种受体的高亲和力，高特异性配体。 在本发明的一个方面，提供了比视黄酸（即，类固醇）对类视黄醇X受体更有选择性的配体。 在本发明的另一方面，已经发现了能够诱导维甲酸受体介导的过程的替代配体（视黄酸除外）。 在另一方面，已经开发了用于从容易获得的化合物制备这种类视黄醇受体配体的方法。

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