发明授权
US07063945B2 N8 -and c8 -linked purine based and structurally related heterocycles as universal nucleosides used oligonucleotides hybridization
有权
N8-和c8连接的基于嘌呤和结构相关的杂环作为通用核苷使用寡核苷酸杂交
- 专利标题： N8 -and c8 -linked purine based and structurally related heterocycles as universal nucleosides used oligonucleotides hybridization
- 专利标题（中）： N8-和c8连接的基于嘌呤和结构相关的杂环作为通用核苷使用寡核苷酸杂交
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申请号： US10221306申请日： 2001-03-27
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公开(公告)号： US07063945B2公开(公告)日： 2006-06-20
- 发明人: Frank Seela , Harald Debelak , Frank Bergmann , Dieter Heindl , Herbert Von Der Eltz
- 申请人： Frank Seela , Harald Debelak , Frank Bergmann , Dieter Heindl , Herbert Von Der Eltz
- 申请人地址： US CA Alameda
- 专利权人： Roche Molecular Systems, Inc
- 当前专利权人： Roche Molecular Systems, Inc
- 当前专利权人地址： US CA Alameda
- 代理商 Charles M. Doyle
- 优先权： EP001060177 20000328; EP001080233 20000420
- 国际申请： PCT/EP01/03458 WO 20010327
- 国际公布： WO01/72764 WO 20011004
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C07H21/00 ; C07H21/02 ; C07H21/04
摘要：
The present invention is directed to a nucleic acid binding compound comprising N8- or C8-linked purine bases or structurally related heterocycles, a compound useful for the preparation of such compound, a binding product of this nucleic acid binding compound with a nucleic acid, a method for the determination of a nucleic acid using said compound, and several uses of 8-linked purine bases and structurally related heterocycles. Compounds according to the present invention have advantageous properties when used in hybridization methods.
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