利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

30 条记录 (耗时 0.023 秒)

    Oligo-2′-deoxynucleotides and their use as pharmaceutical agents with antiviral activity
    2.
    发明授权
    Oligo-2′-deoxynucleotides and their use as pharmaceutical agents with antiviral activity 失效
    寡脱氧核苷酸及其作为具有抗病毒活性的药物的用途

    公开(公告)号：US06329346B1

    公开(公告)日：2001-12-11

    申请号：US08991183

    申请日：1997-12-16

    申请人： Klasu Muhlegger ,  Herbert Von Der Eltz ,  Frank Seela ,  Helmut Rosemeyer

    发明人： Klasu Muhlegger ,  Herbert Von Der Eltz ,  Frank Seela ,  Helmut Rosemeyer

    IPC分类号： A01N4304

    CPC分类号： C07H19/10 ,  C07H19/20 ,  C07H21/00

    摘要： Oligodeoxyribonucleotides in which at least two 2′-deoxy-&bgr;-D-erythro-pentofuranosyl groups are replaced by 2′-deoxy-&bgr;-D-threo-pentofuranosyl groups at both the 5′ end and 3′ end, and oligodeoxyribonucleotides in which at least 20% of the 2′-deoxy-&bgr;-D-erythro-pentofuranosyl groups in consecutive nucleotide building blocks are replaced by 2′-deoxy-&bgr;-D-threo-pentofuranosyl groups and which are composed of 6 to 100 nucleotide building blocks, are suitable for the inhibition of the expression of viral genes and oncogenes by the antisense principle and can be used for the production of pharmaceutical agents with antiviral activity.

    摘要翻译： 在5'末端和3'末端两个脱氧-β-D-赤 - 呋喃糖基被2'-脱氧-β-D-苏 - 戊呋喃糖基取代的寡脱氧核糖核苷酸和其中的寡脱氧核糖核苷酸 连续核苷酸构建单元中2'-脱氧-β-D-赤型 - 戊呋喃糖基的至少20％被2'-脱氧-β-D-苏糖 - 呋喃糖基取代，它们由6至100个核苷酸构建 适用于通过反义原理抑制病毒基因和癌基因的表达，并可用于生产具有抗病毒活性的药剂。

    7-deaza-2'-deoxyguanosine nucleotides
    3.
    发明授权
    7-deaza-2'-deoxyguanosine nucleotides 失效
    7-脱氮-2'-脱氧鸟苷核苷酸

    公开(公告)号：US4804748A

    公开(公告)日：1989-02-14

    申请号：US896657

    申请日：1986-08-13

    申请人： Frank Seela

    发明人： Frank Seela

    IPC分类号： C12Q1/68 ,  C07H19/14 ,  C07H19/20 ,  G01N33/50 ,  C12P1/00

    CPC分类号： C07H19/20 ,  C07H19/14

    摘要： The present invention provides 7-deaza-2'-deoxy-guanosine nucleotides of the general formula: ##STR1## wherein R is a --PO.sub.3 H.sub.2, --P.sub.2 O.sub.6 H.sub.3 or --P.sub.3 O.sub.9 H.sub.4 residue or an alkali metal, alkaline earth metal or ammonium salt of the phosphate groups. The present invention also provides processes for the preparation of these nucleotides and is also concerned with the use thereof in the sequencing of DNA.

    摘要翻译： 本发明提供了以下通式的7-脱氮-2'-脱氧鸟苷核苷酸：其中R是-PO 3 H 2，-P 2 O 6 H 3或-P 3 O 9 H 4残基或磷酸碱金属，碱土金属或铵盐 团体 本发明还提供了制备这些核苷酸的方法，并且还涉及其在DNA测序中的应用。

    CONJUGATE BETWEEN A THIOPHILIC SOLID PHASE AND AN OLIGONUCLEOTIDE COMPRISING A THIOOXONUCLEOTIDE
    4.
    发明申请
    CONJUGATE BETWEEN A THIOPHILIC SOLID PHASE AND AN OLIGONUCLEOTIDE COMPRISING A THIOOXONUCLEOTIDE 有权
    一个硫代固体相与一个含有硫代核苷酸的寡核苷酸之间的结合

    公开(公告)号：US20130210009A1

    公开(公告)日：2013-08-15

    申请号：US13866412

    申请日：2013-04-19

    申请人： Simone Budow ,  Ping Ding ,  Dieter Heindl ,  Alfons Nichtl ,  Frank Seela

    发明人： Simone Budow ,  Ping Ding ,  Dieter Heindl ,  Alfons Nichtl ,  Frank Seela

    IPC分类号： C12Q1/68 ,  C12M1/34 ,  C07H21/02

    CPC分类号： C12Q1/6876 ,  C07H21/02

    摘要： An oligonucleotide-solid phase conjugate, wherein the solid phase is thiophilic and the oligonucleotide comprises at least one thiooxonucleobase according to Formula I, wherein X is CH or N, R1 is H or NH2, --- indicates a covalent bond, and said oligonucleotide is bound to said solid phase via the sulfur atom of said thiooxonucleotide. Also disclosed are methods for producing such conjugate as well as various uses for such oligonucleotide metal conjugate.

    摘要翻译： 一种寡核苷酸 - 固相缀合物，其中所述固相是亲核的，并且所述寡核苷酸包含至少一种根据式I的硫氧基核碱基，其中X为CH或N，R 1为H或NH 2，表示共价键，所述寡核苷酸 通过所述硫代核苷酸的硫原子与所述固相结合。 还公开了用于生产这种缀合物的方法以及这种寡核苷酸金属缀合物的各种用途。

    2-Azapurine compounds and their use
    5.
    发明授权
    2-Azapurine compounds and their use 有权
    2-Azapurine化合物及其用途

    公开(公告)号：US07169553B1

    公开(公告)日：2007-01-30

    申请号：US10070340

    申请日：2000-08-28

    申请人： Frank Seela ,  Helmut Rosenmeyer ,  Enno Schweinberger ,  Dieter Heindl ,  Frank Bergmann

    发明人： Frank Seela ,  Helmut Rosenmeyer ,  Enno Schweinberger ,  Dieter Heindl ,  Frank Bergmann

    IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/00 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C12N15/113 ,  C07H19/04 ,  C07H19/10 ,  C07H19/20 ,  C07H21/00 ,  C12N2310/333 ,  C12Q1/6813

    摘要： Within oligonucleotides 2-azapurine and especially 2-azaadenine bases form specifically base pairs with guanine. This base pair is of analogous stability as an adenine-thymine but less stable than a guanine-cytosine base pair. Therefore, the incorporation of 2-azaadenine residues into oligonucleotides instead of cytosine leads specifically to hybridization complexes with nucleic acids with homogenous stability. This is useful for the adaptation of the stabilities of different oligonucleotide sequences in all kinds of hybridization techniques, for example in oligomer chip technology.

    摘要翻译： 寡核苷酸2-氮杂嘌呤，特别是2-氮杂腺嘌呤碱基与鸟嘌呤特异性碱基对形成。 该碱基对具有与腺嘌呤 - 胸腺嘧啶类似的稳定性，但不如鸟嘌呤 - 胞嘧啶碱基对稳定。 因此，将2-氮杂腺嘌呤残基并入寡核苷酸而不是胞嘧啶，特别导致与具有均匀稳定性的核酸的杂交复合物。 这对于在各种杂交技术中适应不同寡核苷酸序列的稳定性是有用的，例如在低聚物芯片技术中。

    2-deoxy-isoguanosines isosteric analogues and isoguanosine derivatives as well as their synthesis
    7.
    发明授权
    2-deoxy-isoguanosines isosteric analogues and isoguanosine derivatives as well as their synthesis 失效
    2-脱氧 - 异鸟嘌呤等位基因类似物和异鸟苷衍生物及其合成

    公开(公告)号：US06498241B1

    公开(公告)日：2002-12-24

    申请号：US09712454

    申请日：2000-11-13

    申请人： Frank Seela ,  Zigmunt Kasimierczuk ,  Klaus Mühlegger ,  Herbert Von Der Eltz

    发明人： Frank Seela ,  Zigmunt Kasimierczuk ,  Klaus Mühlegger ,  Herbert Von Der Eltz

    IPC分类号： C07H2104

    CPC分类号： C07H21/00 ,  C07H19/04

    摘要： 2′-Deoxyisoguanosine, isosteric analogues and isoguanosine derivatives of formulae I-V, processes for their production via compounds of the general formulae a or b and reaction with aroyl isocyanates or from compounds of the general formulae VI-IX by photochemical irradiation. A further production process is the conversion of deoxyguanosines or guanosines by means of persilylation, reaction with ammonia and deamination in the 2 position. The compounds are suitable as pharmaceutical agents with antiviral efficacy.

    摘要翻译： 2-脱氧异鸟苷，式I-V的异构体类似物和异鸟嘌呤衍生物，其通过通式a或b的化合物生产并通过光化学辐射与芳酰基异氰酸酯或通式VI-IX的化合物反应。 进一步的生产过程是通过去硅藻土或鸟氨酸的转化，通过与二氨基反应和脱氨作用。 该化合物适合作为具有抗病毒功效的药剂。

    Modified oligonucleotides, their preparation and their use
    9.
    发明授权
    Modified oligonucleotides, their preparation and their use 有权
    修饰的寡核苷酸，其制备及其用途

    公开(公告)号：US06479651B1

    公开(公告)日：2002-11-12

    申请号：US09643233

    申请日：2000-08-22

    申请人： Frank Seela ,  Horst Thomas

    发明人： Frank Seela ,  Horst Thomas

    IPC分类号： C12Q168

    CPC分类号： C07H19/10 ,  C07H19/044 ,  C07H19/14 ,  C07H21/00

    摘要： Modified oligonucleotides which possess at least one substituted 7-deazapurine base form more stable hybridization complexes with nucleic acids than unsubstituted analogs. They are useful as inhibitors of gene expression, as probes for detecting nucleic acids, as aids in molecular biology and as pharmaceuticals or diagnostic agents. Processes for preparing them are provided.

    摘要翻译： 具有至少一个取代的7-脱氮嘌呤碱基的修饰的寡核苷酸与核酸形成比未取代的类似物更稳定的杂交复合物。 它们可用作基因表达的抑制剂，作为用于检测核酸的探针，作为分子生物学的辅助物质以及药物或诊断剂。 提供了制备方法。