- 专利标题： Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
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申请号： US09610551申请日： 2000-07-05
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公开(公告)号： US07067284B1公开(公告)日： 2006-06-27
- 发明人: Carlos F. Barbas , Dennis R. Burton , Richard A. Lerner
- 申请人： Carlos F. Barbas , Dennis R. Burton , Richard A. Lerner
- 申请人地址： US CA La Jolla
- 专利权人： The Scripps Research Institute
- 当前专利权人： The Scripps Research Institute
- 当前专利权人地址： US CA La Jolla
- 代理商 Thomas Fitting; Michael J. McCarthy
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; C12N15/13 ; C12N15/01
摘要：
The present invention describes methods for producing antibody libraries, and particularly for increasing antibody library diversity by inducing mutagenesis within the CDR regions of immunoglobulin heavy or light chains that are displayed on the surface of filamentous phage particles comprising the library. The invention also describes oligonucleotides useful for increasing the library diversity, and universal light chains useful in the library production methods.
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