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1.发明授权公开(公告)号：US07067284B1
公开(公告)日：2006-06-27
申请号：US09610551
申请日：2000-07-05
CPC分类号： C07K16/005 , C07K16/40 , C07K16/44 , C07K2317/55 , C07K2317/565 , C12N15/102 , C12N15/1086 , C12N15/1093
摘要： The present invention describes methods for producing antibody libraries, and particularly for increasing antibody library diversity by inducing mutagenesis within the CDR regions of immunoglobulin heavy or light chains that are displayed on the surface of filamentous phage particles comprising the library. The invention also describes oligonucleotides useful for increasing the library diversity, and universal light chains useful in the library production methods.
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2.发明授权Synthetic human neutralizing monoclonal antibodies to human immunodeficiency virus 失效人类免疫缺陷病毒合成人中和单克隆抗体公开(公告)号：US06261558B1
公开(公告)日：2001-07-17
申请号：US08591632
申请日：1996-02-20
IPC分类号： A61K3940
CPC分类号： C07K16/1063 , A61K49/00 , C07K2319/00 , G01N33/56988 , Y10S435/975
摘要： The present invention describes synthetic human monoclonal antibodies that immunoreact with and neutralize human immunodeficiency virus (HIV). The synthetic monoclonal antibodies of this invention exhibit enhanced binding affinity and neutralization ability to gp120. Also disclosed are immunotherapeutic and diagnostic methods of using the monoclonal antibodies, as well as cell lines for producing the monoclonal antibodies.
摘要翻译： 本发明描述了与人免疫缺陷病毒（HIV）免疫反应和中和的合成人单克隆抗体。 本发明的合成单克隆抗体对gp120表现出增强的结合亲和力和中和能力。 还公开了使用单克隆抗体的免疫治疗和诊断方法，以及用于产生单克隆抗体的细胞系。
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3.发明授权Methods for producing antibody libraries using universal or randomized immunoglobulin light chains 失效使用通用或随机免疫球蛋白轻链产生抗体文库的方法
公开(公告)号：US5667988A
公开(公告)日：1997-09-16
申请号：US300386
申请日：1994-09-02
IPC分类号： C12N15/09 , A61K38/00 , A61K49/16 , A61K51/10 , C07H21/00 , C07K7/06 , C07K7/08 , C07K14/705 , C07K16/00 , C07K16/10 , C07K16/40 , C07K16/44 , C12N15/10 , C12P21/08 , C40B40/02 , C12N15/00
CPC分类号： A61K49/16 , A61K51/10 , C07H21/00 , C07K14/705 , C07K16/00 , C07K16/1063 , C07K16/40 , C07K16/44 , C12N15/1037 , C40B40/02 , A61K38/00 , C07K2317/55 , C07K2317/56 , C07K2319/00 , C07K2319/02
摘要： The present invention describes methods for producing antibody libraries, and particularly for increasing antibody library diversity by inducing mutagenesis within the CDR regions of immunoglobulin heavy or light chains that are displayed on the surface of filamentous phage particles comprising the library. The invention also describes oligonucleotides useful for increasing the library diversity, and universal light chains useful in the library production methods.
摘要翻译： 本发明描述了产生抗体文库的方法，特别是通过在包含该文库的丝状噬菌体颗粒的表面上显示的免疫球蛋白重链或轻链的CDR区域内诱导诱变来增加抗体文库多样性。 本发明还描述了可用于增加文库多样性的寡核苷酸，以及在图书馆生产方法中有用的通用轻链。
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4.发明授权Synthetic human neutralizing monoclonal antibodies to human immunodeficiency virus 失效人类免疫缺陷病毒合成人中和单克隆抗体公开(公告)号：US06395275B1
公开(公告)日：2002-05-28
申请号：US09611451
申请日：2000-07-06
IPC分类号： A61K3942
CPC分类号： C07K16/1063 , A61K49/00 , C07K2319/00 , G01N33/56988 , Y10S435/975
摘要： The present invention describes synthetic human monoclonal antibodies that immunoreact with and neutralize human immunodeficiency virus (HIV). The synthetic monoclonal antibodies of this invention exhibit enhanced binding affinity and neutralization ability to gp120. Also disclosed are immunotherapeutic and diagnostic methods of using the monoclonal antibodies, as well as cell lines for producing the monoclonal antibodies.
摘要翻译： 本发明描述了与人免疫缺陷病毒（HIV）免疫反应和中和的合成人单克隆抗体。 本发明的合成单克隆抗体对gp120表现出增强的结合亲和力和中和能力。 还公开了使用单克隆抗体的免疫治疗和诊断方法，以及用于产生单克隆抗体的细胞系。
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5.发明授权Methods for producing antibody libraries using universal or randomized immunoglobulin light chains 失效使用通用或随机免疫球蛋白轻链产生抗体文库的方法
公开(公告)号：US6096551A
公开(公告)日：2000-08-01
申请号：US931645
申请日：1997-09-16
IPC分类号： C12N15/09 , A61K38/00 , A61K49/16 , A61K51/10 , C07H21/00 , C07K7/06 , C07K7/08 , C07K14/705 , C07K16/00 , C07K16/10 , C07K16/40 , C07K16/44 , C12N15/10 , C12P21/08 , C40B40/02 , C12Q1/68 , C07H21/04
CPC分类号： A61K49/16 , A61K51/10 , C07H21/00 , C07K14/705 , C07K16/00 , C07K16/1063 , C07K16/40 , C07K16/44 , C12N15/1037 , C40B40/02 , A61K38/00 , C07K2317/55 , C07K2317/56 , C07K2319/00 , C07K2319/02
摘要： The present invention describes methods for producing antibody libraries, and particularly for increasing antibody library diversity by inducing mutagenesis within the CDR regions of immunoglobulin heavy or light chains that are displayed on the surface of filamentous phage particles comprising the library. The invention also describes oligonucleotides useful for increasing the library diversity, and universal light chains useful in the library production methods.
摘要翻译： 本发明描述了产生抗体文库的方法，特别是通过在包含该文库的丝状噬菌体颗粒的表面上显示的免疫球蛋白重链或轻链的CDR区域内诱导诱变来增加抗体文库多样性。 本发明还描述了可用于增加文库多样性的寡核苷酸，以及在图书馆生产方法中有用的通用轻链。
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公开(公告)号：US5804440A
公开(公告)日：1998-09-08
申请号：US899575
申请日：1997-07-24
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61K49/00 , A61K49/16 , A61K51/10 , A61P31/12 , C07K16/10 , C07K16/40 , C12N5/10 , C12N15/02 , C12P21/08 , G01N33/569 , G01N33/577 , C07H21/04 , C12N5/24
CPC分类号： C07K16/40 , A61K49/16 , A61K51/10 , C07K16/1063 , A61K38/00 , C07K2317/55 , C07K2319/00
摘要： The present invention describes human monoclonal antibodies which immunoreact with and neutralize human immunodeficiency virus (HIV). Also disclosed are immunotherapeutic and diagnostic methods of using the monoclonal antibodies, as well as cell line for producing the monoclonal antibodies.
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公开(公告)号：US5652138A
公开(公告)日：1997-07-29
申请号：US276852
申请日：1994-07-18
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61K49/00 , A61K49/16 , A61K51/10 , A61P31/12 , C07K16/10 , C07K16/40 , C12N5/10 , C12N15/02 , C12P21/08 , G01N33/569 , G01N33/577 , C12N1/21
CPC分类号： C07K16/40 , A61K49/16 , A61K51/10 , C07K16/1063 , A61K38/00 , C07K2317/55 , C07K2319/00
摘要： The present invention describes human monoclonal antibodies which immunoreact with and neutralize human immunodeficiency virus (HIV). Also disclosed are immunotherapeutic and diagnostic methods of using the monoclonal antibodies, as well as cell line for producing the monoclonal antibodies.
摘要翻译： 本发明描述与人免疫缺陷病毒（HIV）免疫反应和中和的人单克隆抗体。 还公开了使用单克隆抗体的免疫治疗和诊断方法，以及用于产生单克隆抗体的细胞系。
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公开(公告)号：US06268488B1
公开(公告)日：2001-07-31
申请号：US09318661
申请日：1999-05-25
IPC分类号： C07H1524
CPC分类号： C07H15/252
摘要： The present invention provides a compound that includes an active therapeutic agent attached to a blocking moiety that is sensitive to the catalytic action of molecules having retro-aldol and retro-Michael catalytic activity, methods for making such compounds and methods of converting such compounds to active therapeutic agents using molecules having aldolase activity.
摘要翻译： 本发明提供了一种化合物，其包含与对具有后 - 醛醇缩合反应的分子的催化作用敏感的阻断部分连接的活性治疗剂和复合迈克尔催化活性，制备这种化合物的方法和将这些化合物转化为活性的方法 使用具有醛缩酶活性的分子的治疗剂。
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9.发明授权Methods for producing polypeptide metal binding sites and compositions thereof 失效产生多肽金属结合位点的方法及其组合物
公开(公告)号：US5679548A
公开(公告)日：1997-10-21
申请号：US77797
申请日：1993-06-14
CPC分类号： C40B40/02 , C07H21/00 , C07K16/00 , C07K16/40 , C12N15/1037 , C07K2317/55
摘要： The present invention describes methods for producing metal binding sites on polypeptides, and particularly for producing metal binding sites within the CDR regions of immunoglobulin heavy or light chains that are displayed on the surface of filamentous phage particles. The invention also describes oligonucleotides useful for preparing the metal binding sites, and human monoclonal antibodies produced by the present methods.
摘要翻译： 本发明描述了在多肽上产生金属结合位点的方法，特别是用于在显示在丝状噬菌体颗粒表面上的免疫球蛋白重链或轻链的CDR区内产生金属结合位点的方法。 本发明还描述了可用于制备金属结合位点的寡核苷酸以及通过本发明方法产生的人单克隆抗体。
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公开(公告)号：US08252902B2
公开(公告)日：2012-08-28
申请号：US10278364
申请日：2002-10-22
IPC分类号： C07K16/00
CPC分类号： A61K49/0058 , A61K47/54 , A61K47/545 , A61K47/642 , A61K47/66 , A61K47/6813 , A61K47/6871 , A61K47/6881 , A61K47/6889 , B82Y5/00 , C07D475/04 , C07K5/0817 , C07K7/06 , C07K14/005 , C07K14/47 , C07K14/5406 , C07K14/575 , C07K14/71 , C07K16/40 , C12N9/0002 , C12N15/115 , C12N2740/16022
摘要： The present invention provides antibody targeting compounds in which the specificity of the antibody has been reprogrammed by covalently or noncovalently linking a targeting agent to the combining site of an antibody. By this approach, the covalently modified antibody takes on the binding specificity of the targeting agent. The compound may have biological activity provided by the targeting agent or by a separate biological agent. Various uses of the invention compounds are provided.
摘要翻译： 本发明提供抗体靶向化合物，其中抗体的特异性已通过共价或非共价连接靶向剂与抗体的结合位点重新编程。 通过这种方法，共价修饰的抗体具有靶向剂的结合特异性。 化合物可以具有由靶向剂或单独的生物制剂提供的生物活性。 提供本发明化合物的各种用途。
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