发明授权
- 专利标题： Methods for screening compounds that bind human COE-2
- 专利标题（中）： 筛选结合人COE-2的化合物的方法
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申请号： US10001227申请日： 2001-11-30
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公开(公告)号： US07081344B2公开(公告)日： 2006-07-25
- 发明人: Rosana Kapeller-Libermann , Inmaculada Silos-Santiago
- 申请人： Rosana Kapeller-Libermann , Inmaculada Silos-Santiago
- 申请人地址： US MA Cambridge
- 专利权人： Millennium Pharmaceuticals, Inc.
- 当前专利权人： Millennium Pharmaceuticals, Inc.
- 当前专利权人地址： US MA Cambridge
- 代理机构： Millennium Pharmaceuticals Inc.
- 主分类号： G01N33/53
- IPC分类号： G01N33/53 ; G01N33/567 ; C12N9/64
摘要：
The invention provides isolated nucleic acid molecules, designated COE-2 nucleic acid molecules, which encode novel carboxylesterase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing COE-2 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a COE-2 gene has been introduced or disrupted. The invention still further provides isolated COE-2 proteins, fusion proteins, antigenic peptides and anti-COE-2 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
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