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    Novel 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 and 33751 molecules and uses therefor
    2.
    发明申请
    Novel 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 and 33751 molecules and uses therefor 审中-公开
    小分子18607,15603,69318,12303,48000,52202,5333,38554,57301,58324,55063,52991,59914,59921和33751分子及其用途

    公开(公告)号：US20090226448A1

    公开(公告)日：2009-09-10

    申请号：US12381747

    申请日：2009-03-16

    申请人： Maria A. Glucksmann ,  Rory A.J. Curtis ,  Jose M. Lora ,  Katherine M. Galvin ,  Inmaculada Silos-Santiago

    发明人： Maria A. Glucksmann ,  Rory A.J. Curtis ,  Jose M. Lora ,  Katherine M. Galvin ,  Inmaculada Silos-Santiago

    IPC分类号： A61K39/395 ,  C12N15/12 ,  C12N5/10 ,  C07K14/47 ,  C07K16/18 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/566 ,  A61K31/7105 ,  A61K38/48 ,  A61K38/17 ,  A61P35/00 ,  A61P43/00

    CPC分类号： C07K14/705 ,  A61K38/00

    摘要： The invention provides isolated nucleic acids molecules, designated 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 and 33751 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 and 33751 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 or 33751 gene has been introduced or disrupted. The invention still further provides isolated 18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 or 33751 proteins, fusion proteins, antigenic peptides and anti-18607, 15603, 69318, 12303, 48000, 52920, 5433, 38554, 57301, 58324, 55063, 52991, 59914, 59921 or 33751 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供分离的核酸分子，命名为18607,15603,69318,12303,48000,52920,5433,38554,57301,58324,55063,52991,59914,59921和33751核酸分子。 本发明还提供反义核酸分子，包含18607,15603,69318,12303,48000,52920,5433,38554,57301,58324,55063,52991,59914,59921和33751核酸分子的重组表达载体，其中宿主细胞 已经引入了表达载体，并且已导入或破坏其中18607,15603,69318,12303,48000,523020,5433,35554,57301,58324,55063,52991,59914,59921或33751基因的非人转基因动物。 本发明还进一步提供了分离的18607,15603,69318,12303,48000,5920,5433,38554,57301,58324,55063,52991,59914,59921或33751蛋白，融合蛋白，抗原肽和抗-18607,15603,69318 ，12303,48000,5920,5433,38554,57301,58324,55063,52991,59914,59921或33751抗体。 还提供了利用本发明组合物的诊断和治疗方法。

    Methods and compositions for treating urological disorders using 1435, 559, 34021, 44099, 25278, 641, 260, 55089, 21407, 42032, 46656, 62553, 302, 323, 12303, 985, 13237, 13601, 18926, 318, 2058 or 6351 molecules
    3.
    发明申请
    Methods and compositions for treating urological disorders using 1435, 559, 34021, 44099, 25278, 641, 260, 55089, 21407, 42032, 46656, 62553, 302, 323, 12303, 985, 13237, 13601, 18926, 318, 2058 or 6351 molecules 审中-公开
    使用1435,549,34021,44099,25278,641,260,55089,21407,42032,4656,52553,302,323,12303,985,13237,13601,18926,318,2058或用于治疗泌尿系统疾病的方法和组合物或 6351分子

    公开(公告)号：US20060088881A1

    公开(公告)日：2006-04-27

    申请号：US11302678

    申请日：2005-12-14

    申请人： Inmaculada Silos-Santiago ,  Venkateswarlu Karicheti

    发明人： Inmaculada Silos-Santiago ,  Venkateswarlu Karicheti

    IPC分类号： C12Q1/68 ,  G01N33/53

    CPC分类号： C12Q1/6883 ,  C12Q2600/158

    摘要： The present invention relates to methods for the diagnosis and treatment of a urological disorder or urological disorders. Specifically, the present invention identifies the differential expression of 1435, 559, 34021, 44099, 25278, 641, 260, 55089, 21407, 42032, 46656, 62553, 302, 323, 12303, 985, 13237, 13601, 18926, 318, 2058 and 6351 genes in tissues relating to urological disorders, relative to their expression in normal, or non-urological disorders, and/or in response to manipulations relevant to a urological disorder. The present invention describes methods for the diagnostic evaluation and prognosis of various urological disorders, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating a urological disorder or urological disorders. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of urological disorders.

    摘要翻译： 本发明涉及诊断和治疗泌尿系统疾病或泌尿系统疾病的方法。 具体而言，本发明鉴别1435,549,34021,44099,25278,641,260,55089,21407,42032,4656,65353,302,232,12303,985,13237,13601,18926,318的差异表达， 相对于其在正常或非泌尿系统疾病中的表达和/或响应于与泌尿系统疾病相关的操作，与泌尿系统疾病相关的组织中的2058和6351个基因。 本发明描述了各种泌尿系统疾病的诊断评估和预后的方法，以及用于鉴定表现出这种病症倾向的受试者。 本发明还提供了鉴定能够调节泌尿系统疾病或泌尿系统疾病的化合物的方法。 本发明还提供了用于鉴定和治疗性使用化合物作为泌尿系统疾病治疗的方法。

    53010, a human carboxylesterase family member and uses thereof
    4.
    发明授权
    53010, a human carboxylesterase family member and uses thereof 失效
    53010，人羧酸酯酶家族成员及其用途

    公开(公告)号：US06664091B2

    公开(公告)日：2003-12-16

    申请号：US10023515

    申请日：2001-12-18

    申请人： Rory A. J. Curtis ,  Inmaculada Silos-Santiago

    发明人： Rory A. J. Curtis ,  Inmaculada Silos-Santiago

    IPC分类号： C12N918

    CPC分类号： C12N9/18

    摘要： The invention provides isolated nucleic acids molecules, designated 53010 nucleic acid molecules, which encode novel carboxylesterase members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 53010 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 53010 gene has been introduced or disrupted. The invention still further provides isolated 53010 proteins, fusion proteins, antigenic peptides and anti-53010 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供分离的核酸分子，命名为53010核酸分子，其编码新的羧酸酯酶成员。 本发明还提供了反义核酸分子，含有53010个核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及53010基因被引入或破坏的非人转基因动物。 本发明还进一步提供了分离的53010蛋白，融合蛋白，抗原肽和抗-53010抗体。 还提供了利用本发明组合物的诊断方法。

    Methods and compositions for treating urological disorders using carboxypeptidase Z identified as 8263
    6.
    发明授权
    Methods and compositions for treating urological disorders using carboxypeptidase Z identified as 8263 有权
    使用羧肽酶Z鉴定为8263的泌尿系统疾病的方法和组合物

    公开(公告)号：US07258971B2

    公开(公告)日：2007-08-21

    申请号：US10757262

    申请日：2004-01-14

    申请人： Venkateswarlu Karicheti ,  Inmaculada Silos-Santiago ,  Scott D. Eliasof

    发明人： Venkateswarlu Karicheti ,  Inmaculada Silos-Santiago ,  Scott D. Eliasof

    IPC分类号： C12Q1/00 ,  A61K39/00

    CPC分类号： C07K14/47

    摘要： The present invention relates to methods for the diagnosis and treatment of a urological disorder or urological disorders. Specifically, the present invention identifies the differential expression of Carboxypeptidase Z, identified as “8263” gene in tissues relating to urological disorder, relative to their expression in normal, or non-urological disorder disease states, and/or in response to manipulations relevant to a urological disorder. The present invention describes methods for the diagnostic evaluation and prognosis of various urological diseases, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating a urological disorder or urological disorders. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of urological disorders.

    摘要翻译： 本发明涉及诊断和治疗泌尿系统疾病或泌尿系统疾病的方法。 具体而言，本发明鉴定了相对于在正常或非泌尿疾病疾病状态下的表达，和/或响应于与泌尿系疾病相关的操作相关的与泌尿系疾病相关的组织中鉴定为“8263”基因的羧肽酶Z的差异表达 泌尿系统疾病 本发明描述了各种泌尿疾病的诊断评估和预后的方法，以及用于鉴定表现出这种病症倾向的受试者。 本发明还提供了鉴定能够调节泌尿系统疾病或泌尿系统疾病的化合物的方法。 本发明还提供了用于鉴定和治疗性使用化合物作为泌尿系统疾病治疗的方法。

    Novel nucleic acid sequences encoding G-protein coupled receptors
    8.
    发明申请
    Novel nucleic acid sequences encoding G-protein coupled receptors 审中-公开
    编码G蛋白偶联受体的新型核酸序列

    公开(公告)号：US20060275866A1

    公开(公告)日：2006-12-07

    申请号：US11268745

    申请日：2005-11-07

    申请人： Katherine Galvin ,  Maria Glucksmann ,  Martin Hodge ,  John Hunter ,  Laura Rudolph-Owen ,  Inmaculada Silos-Santiago ,  Nadine Weich

    发明人： Katherine Galvin ,  Maria Glucksmann ,  Martin Hodge ,  John Hunter ,  Laura Rudolph-Owen ,  Inmaculada Silos-Santiago ,  Nadine Weich

    IPC分类号： C07K14/705 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C07K14/705

    摘要： The invention provides isolated nucleic acids molecules, designated 2871, 14926, 44576, 23992, 1983, 52881, 2398, and 52872 nucleic acid molecules, which encode novel G protein-coupled receptor family members that encode novel polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 2871, 14926, 44576, 23992, 1983, 52881, 2398, or 52872 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 2871, 14926, 44576, 23992, 1983, 52881, 2398, or 52872 gene has been introduced or disrupted. The invention still further provides isolated 2871, 14926, 44576, 23992, 1983, 52881, 2398, or 52872 proteins, fusion proteins, antigenic peptides and anti-2871, 14926, 44576, 23992, 1983, 52881, 2398, or 52872 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供分离的核酸分子，命名为2871,14926,4457,239992,1983,52881,2988和52872核酸分子，其编码编码新多肽的新型G蛋白偶联受体家族成员。 本发明还提供反义核酸分子，含有2871,14926,4576,23992,1983,52881,2398或52872核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及非人转基因动物，其中 已经引入或破坏了2871,14926,44576,23992,1983,52881,2398或52872基因。 本发明还进一步提供了分离的2871,14926,4457,239992,1983,52881,2398或52872蛋白质，融合蛋白，抗原肽和抗-2871,14926,4457,23992,1983,52881,29898或52872抗体。 还提供了利用本发明组合物的诊断方法。

    Methods for screening compounds that bind human COE-2
    9.
    发明授权
    Methods for screening compounds that bind human COE-2 失效
    筛选结合人COE-2的化合物的方法

    公开(公告)号：US07081344B2

    公开(公告)日：2006-07-25

    申请号：US10001227

    申请日：2001-11-30

    申请人： Rosana Kapeller-Libermann ,  Inmaculada Silos-Santiago

    发明人： Rosana Kapeller-Libermann ,  Inmaculada Silos-Santiago

    IPC分类号： G01N33/53 ,  G01N33/567 ,  C12N9/64

    CPC分类号： C12N9/18 ,  A61K38/00 ,  C12Y301/01001

    摘要： The invention provides isolated nucleic acid molecules, designated COE-2 nucleic acid molecules, which encode novel carboxylesterase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing COE-2 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a COE-2 gene has been introduced or disrupted. The invention still further provides isolated COE-2 proteins, fusion proteins, antigenic peptides and anti-COE-2 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供分离的核酸分子，命名为COE-2核酸分子，其编码新的羧酸酯酶家族成员。 本发明还提供反义核酸分子，含有COE-2核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及其中引入或破坏了COE-2基因的非人转基因动物。 本发明还进一步提供分离的COE-2蛋白，融合蛋白，抗原肽和抗COE-2抗体。 还提供了利用本发明组合物的诊断和治疗方法。

    Novel TWIK-6, TWIK-7, IC23927, TWIK-8, IC47611, IC47615, HNMDA-1, TWIK-9, alpha2delta-4, 8099, 46455, 54414, 53763, 97076, 97102, 44181, 67084Fl and 67084alt molecules and uses therefor
    10.
    发明申请
    Novel TWIK-6, TWIK-7, IC23927, TWIK-8, IC47611, IC47615, HNMDA-1, TWIK-9, alpha2delta-4, 8099, 46455, 54414, 53763, 97076, 97102, 44181, 67084Fl and 67084alt molecules and uses therefor 审中-公开
    新颖的TWIK-6，TWIK-7，IC23927，TWIK-8，IC47611，IC47615，HNMDA-1，TWIK-9，α2delta-4,8099,46455,5414,53763,97076,97102,44181,67084F1和67084altalt分子， 用它

    公开(公告)号：US20080032289A1

    公开(公告)日：2008-02-07

    申请号：US11050947

    申请日：2005-02-04

    申请人： Rory A.J. Curtis ,  Maria Alexandra Glucksmann ,  Inmaculada Silos-Santiago

    发明人： Rory A.J. Curtis ,  Maria Alexandra Glucksmann ,  Inmaculada Silos-Santiago

    IPC分类号： C07K14/435 ,  C07K16/18 ,  C12N1/00 ,  C12N15/12 ,  C12N15/63 ,  C12N5/00 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/68

    CPC分类号： G01N33/57415 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  C07K14/705 ,  C07K16/18 ,  C07K2319/00 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57434 ,  G01N33/6872 ,  G01N2800/32 ,  G01N2800/325 ,  Y10T436/143333

    摘要： The invention provides isolated nucleic acids molecules, designated TWIK-6, TWIK-7, IC23927, TWIK-8, IC47611, IC47615, HNMDA-1, TWIK-9, α2δ-4, 8099, 46455, 54414, 53763, 97076, 97102, 44181, 67084FL and 67084alt nucleic acid molecules, which encode novel ion channel family molecules, including calcium channels, potassium channels, and NMDA receptors. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing TWIK-6, TWIK-7, IC23927, TWIK-8, IC47611, IC47615, HNMDA-1, TWIK-9, α2δ-4, 8099, 46455, 54414, 53763, 97076, 97102, 44181, 67084FL and 67084alt nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a TWIK-6, TWIK-7, IC23927, TWIK-8, IC47611, IC47615, HNMDA-1, TWIK-9, α2δ-4, 8099, 46455, 54414, 53763, 97076, 97102, 44181, 67084FL and 67084alt gene has been introduced or disrupted. The invention still further provides isolated TWIK-6, TWIK-7, IC23927, TWIK-8, IC47611, IC47615, HNMDA-1, TWIK-9, α2δ-4, 8099, 46455, 54414, 53763, 97076, 97102, 44181, 67084FL and 67084alt polypeptides, fusion polypeptides, antigenic peptides and anti-TWIK-6, TWIK-7, IC23927, TWIK-8, IC47611, IC47615, HNMDA-1, TWIK-9, α2δ-4, 8099, 46455, 54414, 53763, 97076, 97102, 44181, 67084FL and 67084alt antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供分离的核酸分子，称为TWIK-6，TWIK-7，IC23927，TWIK-8，IC47611，IC47615，HNMDA-1，TWIK-9，α2Δ-4,8099， 46455,55414,53763,97076,97102,44181,67084FL和67084alt核酸分子，其编码新的离子通道家族分子，包括钙通道，钾通道和NMDA受体。 本发明还提供反义核酸分子，含有TWIK-6，TWIK-7，IC23927，TWIK-8，IC47611，IC47615，HNMDA-1，TWIK-9，α2Δ- 4,8099,46455,54144,53763,97076,97102,44181,67084FL和67084alt核酸分子，其中引入了表达载体的宿主细胞，以及非人转基因动物，其中TWIK-6，TWIK-7 ，IC23927，TWIK-8，IC47611，IC47615，HNMDA-1，TWIK-9，α2Δ-4,8099,46455,5414,53763,97076,97102,44181,67084FL和67084alt基因 已被引入或中断。 本发明还进一步提供了分离的TWIK-6，TWIK-7，IC23927，TWIK-8，IC47611，IC47615，HNMDA-1，TWIK-9，α2ΔΔ4,8099,46455,5444 ，53763,97076,97102,44181,67084FL和67084alt多肽，融合多肽，抗原肽和抗TWIK-6，TWIK-7，IC23927，TWIK-8，IC47611，IC47615，HNMDA-1，TWIK-9， 3Δ-4，8099,46455,5414,53763,97076,97102,44181,67084FL和67084alt抗体。 还提供了利用本发明组合物的诊断和治疗方法。