Invention Grant
US07087808B2 Method for expressing multiple recombinant proteins in milk of transgenic non-human mammals
有权
用于在转基因非人哺乳动物的乳中表达多种重组蛋白的方法
- Patent Title: Method for expressing multiple recombinant proteins in milk of transgenic non-human mammals
- Patent Title (中): 用于在转基因非人哺乳动物的乳中表达多种重组蛋白的方法
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Application No.: US10790720Application Date: 2004-03-03
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Publication No.: US07087808B2Publication Date: 2006-08-08
- Inventor: Shinn Chih Wu , Teng Kuei Cheng , Chuan Mu Chen , Shau Ping Lin , Chon Ho Yen , Ping Cheng Yang
- Applicant: Shinn Chih Wu , Teng Kuei Cheng , Chuan Mu Chen , Shau Ping Lin , Chon Ho Yen , Ping Cheng Yang
- Applicant Address: TW Miaoli
- Assignee: Animal Technology Institute Taiwan
- Current Assignee: Animal Technology Institute Taiwan
- Current Assignee Address: TW Miaoli
- Agency: Bacon & Thomas, PLLC
- Priority: TW92132541A 20031120
- Main IPC: C12P21/00
- IPC: C12P21/00 ; A01K67/00 ; A01K67/027 ; C12N15/00 ; C07H21/04
Abstract:
The present invention discloses a method for expressing multiple recombinant proteins in transgenic non-human mammalian milk, characterized in which human clotting factor IX gene and porcine lactoferrin gene are transferred into the mammal by gene injection and embryonic implantation to obtain expression in the milk of transgenic mammal and its filial generation. The method of this invention can maintain the stable expression of multiple recombinant proteins in the transgenic mammal during lactation and stable expression amount proximate to that of the first generation in the offsprings of the transgenic non-human mammal.
Public/Granted literature
- US20050114911A1 Method for expressing multiple recombinant proteins in milk of transgenic non-human mammals Public/Granted day:2005-05-26
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