发明授权
US07105167B2 Methods for treating clinical manifestations of GH/GF axis dysregulation by administration of an IGF-I variant
有权
通过施用IGF-I变体治疗GH / GF轴失调的临床表现的方法
- 专利标题： Methods for treating clinical manifestations of GH/GF axis dysregulation by administration of an IGF-I variant
- 专利标题（中）： 通过施用IGF-I变体治疗GH / GF轴失调的临床表现的方法
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申请号： US10028410申请日： 2001-12-19
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公开(公告)号： US07105167B2公开(公告)日： 2006-09-12
- 发明人: Yves Dubaquie , Paul J. Fielder , Henry B. Lowman , Deborah L. Mortensen
- 申请人： Yves Dubaquie , Paul J. Fielder , Henry B. Lowman , Deborah L. Mortensen
- 申请人地址： US CA South San Francisco
- 专利权人： Genentech, Inc.
- 当前专利权人： Genentech, Inc.
- 当前专利权人地址： US CA South San Francisco
- 代理商 Elizabeth M. Barnes; Mark T. Kresnak; Ginger R. Dreger
- 主分类号： A61K38/30
- IPC分类号： A61K38/30 ; C07K14/65
摘要：
IGF-I variants having an alanine, glycine, or serine amino acid residue at position 16, 25, 49 or at positions 3 and 49 of native-sequence IGF-I are provided that are useful to treat a disorder characterized by dysregulation of the GH/IGF axis in a mammal, such as a renal disorder.
公开/授权文献
- US20020160955A1 Protein variants 公开/授权日：2002-10-31