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公开(公告)号：US08110548B2
公开(公告)日：2012-02-07
申请号：US11934582
申请日：2007-11-02
申请人： Yvonne Man-Yee Chen , Ross G. Clark , Andrea G. Cochran , Yves Dubaquie , Paul J. Fielder , Ellen Filvaroff , Henry B. Lowman , Deborah L. Mortensen , Iain C. A. F. Robinson , Nicholas J. Skelton
发明人： Yvonne Man-Yee Chen , Ross G. Clark , Andrea G. Cochran , Yves Dubaquie , Paul J. Fielder , Ellen Filvaroff , Henry B. Lowman , Deborah L. Mortensen , Iain C. A. F. Robinson , Nicholas J. Skelton
IPC分类号： A61K38/00
CPC分类号： C07K7/08 , A61K38/1709 , A61K38/30 , C07K14/4743 , C07K14/65 , C07K2319/00 , A61K2300/00
摘要： The present invention relates to a method for the treatment of a cartilage disorder, including cartilage damaged by injury or degenerative cartilagenous disorders. The method involves contacting the cartilage with an IGF-1 analog with altered affinity for IGF-binding proteins (IGFBPs) or an IGFBP displacer peptide that prevents the interaction of an IGF with an IGFBP and does not bind to a human IGF receptor.
摘要翻译： 本发明涉及一种治疗软骨障碍的方法，包括由损伤或退行性软骨疾病损伤的软骨。 该方法包括使软骨与IGF-1类似物接触，IGF-1类似物对IGF结合蛋白（IGFBPs）或IGFBP替代肽具有改变的亲和性，所述IGFBP置换肽阻止IGF与IGFBP的相互作用并且不结合人IGF受体。
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公开(公告)号：US08097587B2
公开(公告)日：2012-01-17
申请号：US11512046
申请日：2006-08-28
摘要： IGF-I variants having an alanine, glycine, or serine amino acid residue at position 16, 25, 49 or at positions 3 and 49 of native-sequence IGF-I are provided that are useful to treat a disorder characterized by dysregulation of the GH/IGF axis in a mammal, such as a renal disorder.
摘要翻译： 提供了在天然序列IGF-1的第16,25,49位或第3和49位具有丙氨酸，甘氨酸或丝氨酸氨基酸残基的IGF-1变体，其可用于治疗以GH的失调为特征的疾病 / IGF轴在哺乳动物，例如肾脏疾病。
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公开(公告)号：US20090011988A1
公开(公告)日：2009-01-08
申请号：US11929468
申请日：2007-10-30
申请人： Yvonne Man-Yee Chen , Ross G. Clark , Andrea G. Cochran , Yves Dubaquie , Paul J. Fielder , Ellen Filvaroff , Henry B. Lowman , Deborah L. Mortensen , Iain C.A.F. Robinson , Nicholas J. Skelton
发明人： Yvonne Man-Yee Chen , Ross G. Clark , Andrea G. Cochran , Yves Dubaquie , Paul J. Fielder , Ellen Filvaroff , Henry B. Lowman , Deborah L. Mortensen , Iain C.A.F. Robinson , Nicholas J. Skelton
CPC分类号： C07K7/08 , A61K38/1709 , A61K38/30 , C07K14/4743 , C07K14/65 , C07K2319/00 , A61K2300/00
摘要： The present invention relates to a method for the treatment of a cartilage disorder, including cartilage damaged by injury or degenerative cartilagenous disorders. The method involves contacting the cartilage with an IGF-1 analog with altered affinity for IGF-binding proteins (IGFBPs) or an IGFBP displacer peptide that prevents the interaction of an IGF with an IGFBP and does not bind to a human IGF receptor.
摘要翻译： 本发明涉及一种治疗软骨障碍的方法，包括由损伤或退行性软骨疾病损伤的软骨。 该方法包括使软骨与IGF-1类似物接触，IGF-1类似物对IGF结合蛋白（IGFBPs）或IGFBP替代肽具有改变的亲和性，所述IGFBP置换肽阻止IGF与IGFBP的相互作用并且不结合人IGF受体。
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公开(公告)号：US07423017B2
公开(公告)日：2008-09-09
申请号：US10271869
申请日：2002-10-16
申请人： Yvonne Man-Yee Chen , Ross G. Clark , Andrea G. Cochran , Yves Dubaquie , Paul J. Fielder , Ellen Filvaroff , Henry B. Lowman , Deborah L. Mortensen , Iain C. A. F. Robinson , Nicholas J. Skelton
发明人： Yvonne Man-Yee Chen , Ross G. Clark , Andrea G. Cochran , Yves Dubaquie , Paul J. Fielder , Ellen Filvaroff , Henry B. Lowman , Deborah L. Mortensen , Iain C. A. F. Robinson , Nicholas J. Skelton
IPC分类号： A61K38/00
CPC分类号： C07K7/08 , A61K38/1709 , A61K38/30 , C07K14/4743 , C07K14/65 , C07K2319/00 , A61K2300/00
摘要： The present invention relates to a method for the treatment of a cartilage disorder, including cartilage damaged by injury or degenerative cartilagenous disorders. The method involves contacting the cartilage with an IGF-1 analog with altered affinity for IGF-binding proteins (IGFBPs) or an IGFBP displacer peptide that prevents the interaction of an IGF with an IGFBP and does not bind to a human IGF receptor.
摘要翻译： 本发明涉及一种治疗软骨障碍的方法，包括由损伤或退行性软骨疾病损伤的软骨。 该方法包括使软骨与IGF-1类似物接触，IGF-1类似物对IGF结合蛋白（IGFBPs）或IGFBP替代肽具有改变的亲和性，所述IGFBP置换肽阻止IGF与IGFBP的相互作用并且不结合人IGF受体。
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公开(公告)号：US07947650B2
公开(公告)日：2011-05-24
申请号：US11929468
申请日：2007-10-30
申请人： Yvonne Man-Yee Chen , Ross G. Clark , Andrea G. Cochran , Yves Dubaquie , Paul J. Fielder , Ellen Filvaroff , Henry B. Lowman , Deborah L. Mortensen , Iain C. A. F. Robinson , Nicholas J. Skelton
发明人： Yvonne Man-Yee Chen , Ross G. Clark , Andrea G. Cochran , Yves Dubaquie , Paul J. Fielder , Ellen Filvaroff , Henry B. Lowman , Deborah L. Mortensen , Iain C. A. F. Robinson , Nicholas J. Skelton
IPC分类号： A61K38/30
CPC分类号： C07K7/08 , A61K38/1709 , A61K38/30 , C07K14/4743 , C07K14/65 , C07K2319/00 , A61K2300/00
摘要： The present invention relates to a method for the treatment of a cartilage disorder, including cartilage damaged by injury or degenerative cartilagenous disorders. The method involves contacting the cartilage with an IGF-1 analog with altered affinity for IGF-binding proteins (IGFBPs) or an IGFBP displacer peptide that prevents the interaction of an IGF with an IGFBP and does not bind to a human IGF receptor.
摘要翻译： 本发明涉及一种治疗软骨障碍的方法，包括由损伤或退行性软骨疾病损伤的软骨。 该方法包括使软骨与IGF-1类似物接触，IGF-1类似物对IGF结合蛋白（IGFBPs）或IGFBP替代肽具有改变的亲和性，所述IGFBP置换肽阻止IGF与IGFBP的相互作用并且不结合人IGF受体。
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公开(公告)号：US20110003746A1
公开(公告)日：2011-01-06
申请号：US11512046
申请日：2006-08-28
摘要： IGF-I variants having an alanine, glycine, or serine amino acid residue at position 16, 25, 49 or at positions 3 and 49 of native-sequence IGF-I are provided that are useful to treat a disorder characterized by dysregulation of the GH/IGF axis in a mammal, such as a renal disorder.
摘要翻译： 提供了在天然序列IGF-1的第16,25,49位或第3和49位具有丙氨酸，甘氨酸或丝氨酸氨基酸残基的IGF-1变体，其可用于治疗以GH的失调为特征的疾病 / IGF轴在哺乳动物，例如肾脏疾病。
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公开(公告)号：US20100130411A1
公开(公告)日：2010-05-27
申请号：US11934582
申请日：2007-11-02
申请人： Yvonne Man-Yee Chen , Ross G. Clark , Andrea G. Cochran , Yves Dubaquie , Paul J. Fielder , Ellen Filvaroff , Henry B. Lowman , Deborah L. Mortensen , Iain C.A.F. Robinson , Nicholas J. Skelton
发明人： Yvonne Man-Yee Chen , Ross G. Clark , Andrea G. Cochran , Yves Dubaquie , Paul J. Fielder , Ellen Filvaroff , Henry B. Lowman , Deborah L. Mortensen , Iain C.A.F. Robinson , Nicholas J. Skelton
CPC分类号： C07K7/08 , A61K38/1709 , A61K38/30 , C07K14/4743 , C07K14/65 , C07K2319/00 , A61K2300/00
摘要： The present invention relates to a method for the treatment of a cartilage disorder, including cartilage damaged by injury or degenerative cartilagenous disorders. The method involves contacting the cartilage with an IGF-1 analog with altered affinity for IGF-binding proteins (IGFBPs) or an IGFBP displacer peptide that prevents the interaction of an IGF with an IGFBP and does not bind to a human IGF receptor.
摘要翻译： 本发明涉及一种治疗软骨障碍的方法，包括由损伤或退行性软骨疾病损伤的软骨。 该方法包括使软骨与IGF-1类似物接触，IGF-1类似物对IGF结合蛋白（IGFBPs）或IGFBP替代肽具有改变的亲和性，所述IGFBP置换肽阻止IGF与IGFBP的相互作用并且不结合人IGF受体。
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8.发明授权Methods for treating clinical manifestations of GH/GF axis dysregulation by administration of an IGF-I variant 有权通过施用IGF-I变体治疗GH / GF轴失调的临床表现的方法公开(公告)号：US07105167B2
公开(公告)日：2006-09-12
申请号：US10028410
申请日：2001-12-19
摘要： IGF-I variants having an alanine, glycine, or serine amino acid residue at position 16, 25, 49 or at positions 3 and 49 of native-sequence IGF-I are provided that are useful to treat a disorder characterized by dysregulation of the GH/IGF axis in a mammal, such as a renal disorder.
摘要翻译： 提供了在天然序列IGF-1的第16,25,49位或第3和49位具有丙氨酸，甘氨酸或丝氨酸氨基酸残基的IGF-1变体，其可用于治疗以GH的失调为特征的疾病 / IGF轴在哺乳动物，例如肾脏疾病。
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公开(公告)号：US06509443B1
公开(公告)日：2003-01-21
申请号：US09723896
申请日：2000-11-28
申请人： Yves Dubaquie , Henry Lowman
发明人： Yves Dubaquie , Henry Lowman
IPC分类号： C07K1465
摘要： IGF-I and insulin variants are provided that selectively bind to IGFBP-1 or IGFBP-3. These agonist variants are useful, for example, to improve the half-lives of IGF-I and insulin, respectively.
摘要翻译： 提供了选择性结合IGFBP-1或IGFBP-3的IGF-1和胰岛素变体。 这些激动剂变体可用于分别改善IGF-1和胰岛素的半衰期。
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公开(公告)号：US06506874B1
公开(公告)日：2003-01-14
申请号：US09723981
申请日：2000-11-28
申请人： Yves Dubaquie , Henry Lowman
发明人： Yves Dubaquie , Henry Lowman
IPC分类号： A61K3828
摘要： IGF-I and insulin variants are provided that selectively bind to IGFBP-1 or IGFBP-3. These agonist variants are useful, for example, to improve the half-lives of IGF-I and insulin, respectively.
摘要翻译： 提供了选择性结合IGFBP-1或IGFBP-3的IGF-1和胰岛素变体。 这些激动剂变体可用于分别改善IGF-1和胰岛素的半衰期。
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