发明授权
US07145002B2 Crystalline forms of carbapenem antibiotics and methods of preparation
有权
碳青霉烯类抗生素的结晶形式及其制备方法
- 专利标题: Crystalline forms of carbapenem antibiotics and methods of preparation
- 专利标题(中): 碳青霉烯类抗生素的结晶形式及其制备方法
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申请号: US10485319申请日: 2002-09-20
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公开(公告)号: US07145002B2公开(公告)日: 2006-12-05
- 发明人: Karel M. J. Brands , Raymond Cvetovich , Louis S. Crocker , Michael D. Ward , Amar J. Mahajan , Robert M. Wenslow , John M. Williams , Daniel R. Sidler , Charles Orella , Elizabeth S. Fisher , Ronald Jobson
- 申请人: Karel M. J. Brands , Raymond Cvetovich , Louis S. Crocker , Michael D. Ward , Amar J. Mahajan , Robert M. Wenslow , John M. Williams , Daniel R. Sidler , Charles Orella , Elizabeth S. Fisher , Ronald Jobson
- 申请人地址: unknown Rahway
- 专利权人: Merck & Co. Inc.
- 当前专利权人: Merck & Co. Inc.
- 当前专利权人地址: unknown Rahway
- 代理商 Sylvia A. Ayler; Valerie J. Camara
- 国际申请: PCT/US02/30002 WO 20020920
- 国际公布: WO03/026572 WO 20030403
- 主分类号: C07D477/20
- IPC分类号: C07D477/20
摘要:
A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than −5° C., c) adjusting the pH using a solution containing an acid in an organic solvent to give the appropriate pH for crystallization, and d) crystallizing the compound by adding methanol, and a C2-5 alcohol at between −5 and −25° C.
公开/授权文献
- US20040235817A1 Crystalline forms of ertapenem sodium 公开/授权日:2004-11-25