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公开(公告)号:US06924282B2
公开(公告)日:2005-08-02
申请号:US10218537
申请日:2002-08-14
申请人: Neville J. Anthony , Wei Xu , John V. Lepore , Amar J. Mahajan
发明人: Neville J. Anthony , Wei Xu , John V. Lepore , Amar J. Mahajan
IPC分类号: C07D471/04 , A61K31/4375 , A61P31/18 , A61P43/00 , C07D487/04 , C07D417/14 , A61K31/541
CPC分类号: C07D487/04
摘要: A sodium salt of Compound A is disclosed, wherein Compound A is of formula: Compound A is an HIV integrase inhibitor useful for preventing or treating HIV infection, for delaying the onset of AIDS, and for treating AIDS.
摘要翻译: 公开了化合物A的钠盐,其中化合物A具有下式:化合物A是可用于预防或治疗HIV感染,延迟AIDS发作和用于治疗AIDS的HIV整合酶抑制剂。
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2.
公开(公告)号:US07145002B2
公开(公告)日:2006-12-05
申请号:US10485319
申请日:2002-09-20
申请人: Karel M. J. Brands , Raymond Cvetovich , Louis S. Crocker , Michael D. Ward , Amar J. Mahajan , Robert M. Wenslow , John M. Williams , Daniel R. Sidler , Charles Orella , Elizabeth S. Fisher , Ronald Jobson
发明人: Karel M. J. Brands , Raymond Cvetovich , Louis S. Crocker , Michael D. Ward , Amar J. Mahajan , Robert M. Wenslow , John M. Williams , Daniel R. Sidler , Charles Orella , Elizabeth S. Fisher , Ronald Jobson
IPC分类号: C07D477/20
CPC分类号: C07D477/20
摘要: A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than −5° C., c) adjusting the pH using a solution containing an acid in an organic solvent to give the appropriate pH for crystallization, and d) crystallizing the compound by adding methanol, and a C2-5 alcohol at between −5 and −25° C.
摘要翻译: 制备式IIa的结晶碳青霉烯单钠盐的方法,其特征在于以下步骤:a)向碳青霉烯的水溶液中加入约10至30%的有机溶剂,b)将所得溶液冷却至小于-5℃ c)c)使用在有机溶剂中含有酸的溶液调节pH以得到适当的结晶pH,和d)通过加入甲醇和C 2-5醇来使化合物结晶 在-5和-25℃之间
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3.
公开(公告)号:USRE40794E1
公开(公告)日:2009-06-23
申请号:US11999720
申请日:2002-09-20
申请人: Karel M. J. Brands , Raymond Cvetovich , Louis S. Crocker , Michael D. Ward , Amar J. Mahajan , Robert M. Wenslow , John M. Williams , Daniel R. Sidler , Charles Orella , Elizabeth S. Fisher , Ronald Jobson
发明人: Karel M. J. Brands , Raymond Cvetovich , Louis S. Crocker , Michael D. Ward , Amar J. Mahajan , Robert M. Wenslow , John M. Williams , Daniel R. Sidler , Charles Orella , Elizabeth S. Fisher , Ronald Jobson
IPC分类号: C07D477/20
CPC分类号: C07D477/20
摘要: A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than −5° C., c) adjusting the pH using a solution containing an acid in an organic solvent to give the appropriate pH for crystallization, and d) crystallizing the compound by adding methanol, and a C2-5 alcohol at between −5 and −25° C.
摘要翻译: 制备式IIa的结晶碳青霉烯单钠盐的方法,其特征在于以下步骤:a)向碳青霉烯的水溶液中加入约10至30%的有机溶剂,b)将所得溶液冷却至小于-5℃ c)c)使用在有机溶剂中含有酸的溶液调节pH以得到适当的结晶pH,和d)通过加入甲醇和C2-5醇在-5至-25℃之间使该化合物结晶 C。
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公开(公告)号:US07754731B2
公开(公告)日:2010-07-13
申请号:US11293678
申请日:2005-12-02
申请人: Kevin M. Belyk , Henry G. Morrison , Amar J. Mahajan , Daniel J. Kumke , Hsien-Hsin Tung , Lawrence Wai , Vanessa Pruzinsky
发明人: Kevin M. Belyk , Henry G. Morrison , Amar J. Mahajan , Daniel J. Kumke , Hsien-Hsin Tung , Lawrence Wai , Vanessa Pruzinsky
IPC分类号: C07D239/54 , A61K31/515
CPC分类号: C07D239/557 , C07D313/12 , C07D413/12
摘要: Potassium salts of Compound A and methods for their preparation are disclosed, wherein Compound A is of formula: Compound A is an HIV integrase inhibitor useful for treating or prophylaxis of HIV infection, for delaying the onset of AIDS, and for treating or prophylaxis of AIDS.
摘要翻译: 公开了化合物A的钾盐及其制备方法,其中化合物A具有下式:化合物A是可用于治疗或预防HIV感染,延迟AIDS发作和用于治疗或预防艾滋病的HIV整合酶抑制剂 。
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公开(公告)号:US08357798B2
公开(公告)日:2013-01-22
申请号:US12793801
申请日:2010-06-04
申请人: Kevin M. Belyk , Henry G. Morrison , Philip Jones , Vincenzo Summa , V. Brett Cooper , Amar J. Mahajan , Daniel J. Kumke , Hsien-Hsin Tung , Lawrence Wai , Vanessa Pruzinsky , Philip Pye , Remy Angelaud , Danny Mancheno
发明人: Kevin M. Belyk , Henry G. Morrison , Philip Jones , Vincenzo Summa , V. Brett Cooper , Amar J. Mahajan , Daniel J. Kumke , Hsien-Hsin Tung , Lawrence Wai , Vanessa Pruzinsky , Philip Pye , Remy Angelaud , Danny Mancheno
IPC分类号: C07D239/54
CPC分类号: C07D239/557 , C07D313/12 , C07D413/12
摘要: Potassium salts of Compound A and methods for their preparation are disclosed, wherein Compound A is of formula: Compound A is an HIV integrase inhibitor useful for treating or prophylaxis of HIV infection, for delaying the onset of AIDS, and for treating or prophylaxis of AIDS.
摘要翻译: 公开了化合物A的钾盐及其制备方法,其中化合物A具有下式:化合物A是可用于治疗或预防HIV感染,延迟AIDS发作和用于治疗或预防艾滋病的HIV整合酶抑制剂 。
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