发明授权
- 专利标题： Major neutralization site of hepatitis E virus and use of this neutralization site in methods of vaccination and in methods of screening for neutralizing antibodies to hepatitis E virus
- 专利标题（中）： 丙型肝炎病毒的主要中和位点，以及在接种方法中使用该中和部位和筛选中和乙型肝炎病毒抗体的方法
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申请号： US11054041申请日： 2005-02-09
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公开(公告)号： US07148323B2公开(公告)日： 2006-12-12
- 发明人: Darren Schofield , Suzanne U. Emerson , Robert H. Purcell
- 申请人： Darren Schofield , Suzanne U. Emerson , Robert H. Purcell
- 申请人地址： US DC Washington
- 专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人地址： US DC Washington
- 代理机构： Knobbe, Martens, Olson & Bear, LLP
- 主分类号： C12P21/08
- IPC分类号： C12P21/08 ; C07K16/08 ; A61K39/42 ; A61K39/29 ; G01N33/53 ; A61K39/395
摘要：
The invention describes the identification of a major neutralization site of hepatitis E virus (HEV) and the use of this neutralization site in methods of vaccination and in methods of screening for neutralizing antibodies to HEV. The invention also describes the isolation and characterization of neutralizing chimpanzee monoclonal antibodies reactive to the neutralization site and the use of these antibodies in the diagnosis, treatment and prevention of HEV.
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