发明授权
US07153951B2 Bioactive peptides and peptide derivatives of parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP)
有权
甲状旁腺激素（PTH）和甲状旁腺激素相关肽（PTHrP）的生物活性肽和肽衍生物
- 专利标题： Bioactive peptides and peptide derivatives of parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP)
- 专利标题（中）： 甲状旁腺激素（PTH）和甲状旁腺激素相关肽（PTHrP）的生物活性肽和肽衍生物
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申请号： US10192673申请日： 2002-07-11
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公开(公告)号： US07153951B2公开(公告)日： 2006-12-26
- 发明人: Thomas J Gardella , Henry M Kronenberg , John T Potts, Jr. , Harald Jüppner
- 申请人： Thomas J Gardella , Henry M Kronenberg , John T Potts, Jr. , Harald Jüppner
- 申请人地址： US MA Boston
- 专利权人： The General Hospital Corporation
- 当前专利权人： The General Hospital Corporation
- 当前专利权人地址： US MA Boston
- 代理机构： Sterne, Kessler, Goldstein & Fox P.L.L.C.
- 主分类号： C07H21/04
- IPC分类号： C07H21/04 ; C12N15/63 ; A61K38/00
摘要：
Novel parathyroid hormone peptide (PTH) and parathyroid hormone related peptide (PTHrP) or derivatives thereof which are biologically active are disclosed, as are pharmaceutical compositions containing such peptides, and synthetic and recombinant methods for producing such peptides. Also disclosed are methods for treating mammalian conditions characterized by decreases in bone mass using therapeutically effective pharmaceutical compositions containing such peptides. Also disclosed are methods for screening candidate compounds of the invention for antagonistic or agonistic effects on parathyroid hormone receptor action. Also disclosed are diagnostic and therapeutic methods of such compounds.
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