公开(公告)号：US07153951B2

公开(公告)日：2006-12-26

申请号：US10192673

申请日：2002-07-11

申请人： Thomas J Gardella ,  Henry M Kronenberg ,  John T Potts, Jr. ,  Harald Jüppner

发明人： Thomas J Gardella ,  Henry M Kronenberg ,  John T Potts, Jr. ,  Harald Jüppner

IPC分类号： C07H21/04 ,  C12N15/63 ,  A61K38/00

CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K14/635

摘要： Novel parathyroid hormone peptide (PTH) and parathyroid hormone related peptide (PTHrP) or derivatives thereof which are biologically active are disclosed, as are pharmaceutical compositions containing such peptides, and synthetic and recombinant methods for producing such peptides. Also disclosed are methods for treating mammalian conditions characterized by decreases in bone mass using therapeutically effective pharmaceutical compositions containing such peptides. Also disclosed are methods for screening candidate compounds of the invention for antagonistic or agonistic effects on parathyroid hormone receptor action. Also disclosed are diagnostic and therapeutic methods of such compounds.

摘要翻译： 公开了具有生物活性的新型甲状旁腺激素肽（PTH）和甲状旁腺激素相关肽（PTHrP）或其衍生物，含有这些肽的药物组合物，以及用于生产这些肽的合成和重组方法。 还公开了用于治疗哺乳动物病症的方法，其特征在于使用含有这种肽的治疗有效的药物组合物降低骨量。 还公开了用于筛选本发明的候选化合物对甲状旁腺激素受体作用的拮抗作用或激动作用的方法。 还公开了这些化合物的诊断和治疗方法。