Invention Grant
US07160856B2 α-O-linked glycoconjugates, methods of preparation and uses thereof
有权
α-O-连接的糖缀合物，其制备方法和用途
- Patent Title: α-O-linked glycoconjugates, methods of preparation and uses thereof
- Patent Title (中): α-O-连接的糖缀合物，其制备方法和用途
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Application No.: US10205021Application Date: 2002-07-25
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Publication No.: US07160856B2Publication Date: 2007-01-09
- Inventor: Samuel J. Danishefsky , Dalibor Sames , Samuel Hintermann , Xiao Tao Chen , Jacob B. Schwarz , Peter Glunz , Govindaswami Ragupathi , Philip O. Livingston , Scott Kuduk , Lawrence Williams
- Applicant: Samuel J. Danishefsky , Dalibor Sames , Samuel Hintermann , Xiao Tao Chen , Jacob B. Schwarz , Peter Glunz , Govindaswami Ragupathi , Philip O. Livingston , Scott Kuduk , Lawrence Williams
- Applicant Address: US NY New York
- Assignee: Sloan-Kettering Institute for Cancer Research
- Current Assignee: Sloan-Kettering Institute for Cancer Research
- Current Assignee Address: US NY New York
- Agency: Brenda Herschbach Jarrell Choate, Hall & Stewart, LLP
- Agent Nadège M. Lagneau
- Main IPC: A61K38/14
- IPC: A61K38/14 ; A61K39/385 ; C07K9/00
Abstract:
The present invention provides novel α-O-linked glycoconjugates such as α-O-linked glycopeptides, as well convergent methods for synthesis thereof. The general preparative approach is exemplified by the synthesis of the mucin motif commonly found on epithelial tumor cell surfaces. The present invention further provides compositions and methods of treating cancer using the α-O-linked glycoconjugates.
Public/Granted literature
- US20030083235A1 Alpha-o-linked glycoconjugates, methods of preparation and uses thereof Public/Granted day:2003-05-01
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