Invention Grant
US07169816B2 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors
失效
4-溴或4-碘苯基氨基苯并肟酸衍生物及其作为MEK抑制剂的用途
- Patent Title: 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors
- Patent Title (中): 4-溴或4-碘苯基氨基苯并肟酸衍生物及其作为MEK抑制剂的用途
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Application No.: US11249543Application Date: 2005-10-12
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Publication No.: US07169816B2Publication Date: 2007-01-30
- Inventor: Stephen Douglas Barrett , Alexander James Bridges , Annette Marian Doherty , David Thomas Dudley , Alan Robert Saltiel , Haile Tecle
- Applicant: Stephen Douglas Barrett , Alexander James Bridges , Annette Marian Doherty , David Thomas Dudley , Alan Robert Saltiel , Haile Tecle
- Applicant Address: US NJ Morris Plains
- Assignee: Warner-Lambert Company
- Current Assignee: Warner-Lambert Company
- Current Assignee Address: US NJ Morris Plains
- Agent Bryan C. Zielinski; Galina M. Yakovleva
- Main IPC: A61K31/166
- IPC: A61K31/166 ; C07D233/64
Abstract:
Phenylamino benzhydroxamic acid derivatives of the formula where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and where R7 is hydrogen or an organic radical, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as psoriasis and restenosis.
Public/Granted literature
- US20060052608A1 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors Public/Granted day:2006-03-09
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