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1.发明授权Method of treating or preventing septic shock by administering a MEK inhibitor 失效通过施用MEK抑制剂治疗或预防败血性休克的方法公开(公告)号：US06251943B1
公开(公告)日：2001-06-26
申请号：US09355680
申请日：1999-08-02
申请人： Stephen Douglas Barrett , Alexander James Bridges , Donna Reynolds Cody , Annette Marian Doherty , David Thomas Dudley , Alan Robert Saltiel , Mel Conrad Schroeder , Haile Tecle
发明人： Stephen Douglas Barrett , Alexander James Bridges , Donna Reynolds Cody , Annette Marian Doherty , David Thomas Dudley , Alan Robert Saltiel , Mel Conrad Schroeder , Haile Tecle
IPC分类号： A61K31195
CPC分类号： A61K31/135 , A61K31/165 , A61K31/18 , A61K31/195 , A61K31/34 , A61K31/38 , A61K31/40 , A61K31/41 , A61K31/44 , A61K31/445 , A61K31/495 , A61K31/535 , Y10S514/921
摘要： The present invention provides a method for treating or preventing septic shock. Specifically, the present invention provides a method of treating or preventing septic shock by administering to a patient a MEK inhibitor.
摘要翻译： 本发明提供治疗或预防败血性休克的方法。 具体地，本发明提供了通过向患者施用MEK抑制剂来治疗或预防败血性休克的方法。
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公开(公告)号：US07019033B2
公开(公告)日：2006-03-28
申请号：US10315654
申请日：2002-12-10
申请人： Stephen Douglas Barrett , Alexander James Bridges , Donna Reynolds Cody , Annette Marian Doherty , David Thomas Dudley , Alan Robert Saltiel , Mel Conrad Schroeder , Haile Tecle
发明人： Stephen Douglas Barrett , Alexander James Bridges , Donna Reynolds Cody , Annette Marian Doherty , David Thomas Dudley , Alan Robert Saltiel , Mel Conrad Schroeder , Haile Tecle
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/277 , A61K31/198
CPC分类号： C07D213/40 , C07C215/68 , C07C229/58 , C07C237/08 , C07C237/16 , C07C237/20 , C07C237/30 , C07C237/32 , C07C237/36 , C07C237/38 , C07C239/22 , C07C243/38 , C07C311/44 , C07C2601/02 , C07C2601/14 , C07D257/04 , C07D257/06 , C07D295/13 , C07D295/155 , C07D295/32 , C07D333/20
摘要： Phenylamino benzoic acid, benzamides, and benzyl alcohol derivatives of the formula where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and where R7 is hydrogen or an organic radical, and Z is COOR7, tetrazolyl, CONR6R7, or CH2OR7, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as inflammation, psoriasis and restenosis, as well as stroke, heart failure, and immunodeficiency disorders.
摘要翻译： 苯基氨基苯甲酸，苯甲酰胺和下式的苄醇衍生物其中R 1，R 2，R 3，R 4， R 5，R 5和R 6是氢或取代基如烷基，其中R 7是氢或有机基团 ，Z为COOR 7，四唑基，CONR 6 R 7或CH 2 2或7 是MEK的有效抑制剂，因此在治疗癌症和其它增殖性疾病如炎症，牛皮癣和再狭窄以及中风，心力衰竭和免疫缺陷障碍中都是有效的。
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3.发明授权4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors 失效4-溴或4-碘苯基氨基苯并肟酸衍生物及其作为MEK抑制剂的用途公开(公告)号：US07169816B2
公开(公告)日：2007-01-30
申请号：US11249543
申请日：2005-10-12
申请人： Stephen Douglas Barrett , Alexander James Bridges , Annette Marian Doherty , David Thomas Dudley , Alan Robert Saltiel , Haile Tecle
发明人： Stephen Douglas Barrett , Alexander James Bridges , Annette Marian Doherty , David Thomas Dudley , Alan Robert Saltiel , Haile Tecle
IPC分类号： A61K31/166 , C07D233/64
CPC分类号： C07D295/088 , C07C259/10 , C07D211/22 , C07D213/30 , C07D307/42 , C07D309/06 , C07D333/16
摘要： Phenylamino benzhydroxamic acid derivatives of the formula where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and where R7 is hydrogen or an organic radical, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as psoriasis and restenosis.
摘要翻译： 下式的苯基氨基苯并肟酸衍生物其中R 1，R 2，R 3，R 4，R 4， R 5和R 6是氢或取代基如烷基，并且其中R 7是氢或有机基团是MEK的有效抑制剂 因此，在治疗癌症和其它增殖性疾病如牛皮癣和再狭窄方面是有效的。
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4.发明授权2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors 失效2-（4-溴或4-碘苯基氨基）苯甲酸衍生物及其作为MEK抑制剂的用途公开(公告)号：US06310060B1
公开(公告)日：2001-10-30
申请号：US09462319
申请日：2000-01-05
申请人： Stephen Douglas Barrett , Alexander James Bridges , Donna Reynolds Cody , Annette Marian Doherty , David Thomas Dudley , Alan Robert Saltiel , Mel Conrad Schroeder , Haile Tecle
发明人： Stephen Douglas Barrett , Alexander James Bridges , Donna Reynolds Cody , Annette Marian Doherty , David Thomas Dudley , Alan Robert Saltiel , Mel Conrad Schroeder , Haile Tecle
IPC分类号： A61K31535
CPC分类号： C07D213/40 , C07C215/68 , C07C229/58 , C07C237/08 , C07C237/16 , C07C237/20 , C07C237/30 , C07C237/32 , C07C237/36 , C07C237/38 , C07C239/22 , C07C243/38 , C07C311/44 , C07C2601/02 , C07C2601/14 , C07D257/04 , C07D257/06 , C07D295/13 , C07D295/155 , C07D295/32 , C07D333/20
摘要： Phenylamino benzoic acid, benzamides, and benzyl alcohol derivatives of the formula where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and where R7 is hydrogen or an organic radical, and Z is COOR7, tetrazolyl, CONR6R7, or CH2OR7, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as inflammation, psoriasis and restenosis, as well as stroke, heart failure, and immunodeficiency disorders.
摘要翻译： 式R 1，R 2，R 3，R 4，R 5和R 6的苯基氨基苯甲酸，苯甲酰胺和苄醇衍生物是氢或取代基如烷基，其中R 7是氢或有机基团，Z是COOR 7，四唑基 ，CONR6R7或CH2OR7是MEK的有效抑制剂，因此在治疗癌症和其它增殖性疾病如炎症，牛皮癣和再狭窄以及中风，心力衰竭和免疫缺陷障碍中是有效的。
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5.发明授权4-Bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors 失效4-溴或4-碘苯基氨基苯并肟酸衍生物及其作为MEK抑制剂的用途公开(公告)号：US06821963B2
公开(公告)日：2004-11-23
申请号：US10163890
申请日：2002-06-04
申请人： Stephen Douglas Barrett , Alexander James Bridges , Annette Marian Doherty , David Thomas Dudley , Alan Robert Saltiel , Haile Tecle
发明人： Stephen Douglas Barrett , Alexander James Bridges , Annette Marian Doherty , David Thomas Dudley , Alan Robert Saltiel , Haile Tecle
IPC分类号： A61K31397
CPC分类号： C07D295/088 , C07C259/10 , C07D211/22 , C07D213/30 , C07D307/42 , C07D309/06 , C07D333/16
摘要： Phenylamino benzhydroxamic acid derivatives of formula (I) where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and where R7 is hydrogen or an organic radical, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as psoriasis and restenosis.
摘要翻译： 其中R 1，R 2，R 3，R 4，R 5和R 6是氢或取代基如烷基，且其中R 7是氢或有机基团的式（I）的苯基氨基苯并肟酸衍生物是MEK的有效抑制剂 ，有效治疗癌症和其他增殖性疾病如牛皮癣和再狭窄。
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公开(公告)号：US06492363B2
公开(公告)日：2002-12-10
申请号：US09931596
申请日：2001-08-16
申请人： Stephen Douglas Barrett , Alexander James Bridges , Donna Reynolds Cody , Annette Marian Doherty , David Thomas Dudley , Alan Robert Saltiel , Mel Conrad Schroeder , Haile Tecle
发明人： Stephen Douglas Barrett , Alexander James Bridges , Donna Reynolds Cody , Annette Marian Doherty , David Thomas Dudley , Alan Robert Saltiel , Mel Conrad Schroeder , Haile Tecle
IPC分类号： A61K31535
CPC分类号： C07D213/40 , C07C215/68 , C07C229/58 , C07C237/08 , C07C237/16 , C07C237/20 , C07C237/30 , C07C237/32 , C07C237/36 , C07C237/38 , C07C239/22 , C07C243/38 , C07C311/44 , C07C2601/02 , C07C2601/14 , C07D257/04 , C07D257/06 , C07D295/13 , C07D295/155 , C07D295/32 , C07D333/20
摘要： Phenylamino benzoic acid, benzamides, and benzyl alcohol derivatives of the formula where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and where R7 is hydrogen or an organic radical, and Z is COOR7, tetrazolyl, CONR6R7, or CH2OR7, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as inflammation, psoriasis and restenosis, as well as stroke, heart failure, and immunodeficiency disorders.
摘要翻译： 式R 1，R 2，R 3，R 4，R 5和R 6的苯基氨基苯甲酸，苯甲酰胺和苄醇衍生物是氢或取代基如烷基，其中R 7是氢或有机基团，Z是COOR 7，四唑基 ，CONR6R7或CH2OR7是MEK的有效抑制剂，因此在治疗癌症和其它增殖性疾病如炎症，牛皮癣和再狭窄以及中风，心力衰竭和免疫缺陷障碍中是有效的。
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公开(公告)号：US07030119B1
公开(公告)日：2006-04-18
申请号：US10031037
申请日：2000-07-05
申请人： Stephen Douglas Barrett , Alexander James Bridges , Haile Tecle , Alistair Dixon , Kevin Lee , Robert Pinnock
发明人： Stephen Douglas Barrett , Alexander James Bridges , Haile Tecle , Alistair Dixon , Kevin Lee , Robert Pinnock
IPC分类号： A61K31/495 , A61K31/41 , A61K31/425
CPC分类号： A61K31/41 , A61K31/425 , A61K31/495
摘要： The invention features a method for treating chronic pain using a compound of formula (I).
摘要翻译： 本发明的特征在于使用式（I）化合物治疗慢性疼痛的方法。
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公开(公告)号：US06545030B1
公开(公告)日：2003-04-08
申请号：US09889104
申请日：2002-01-17
IPC分类号： A61K3141
CPC分类号： C07D291/04 , A61K45/06 , C07D231/20 , C07D231/46 , C07D249/06 , C07D249/12 , C07D249/14 , C07D257/04 , C07D263/10 , C07D271/07 , C07D275/03 , C07D285/08
摘要： 1-Heterocycle substituted diarylamines, methods of making and using them, and compositions containing them.
摘要翻译： 1-杂环取代的二芳基胺，其制备和使用方法，以及含有它们的组合物。
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公开(公告)号：US06440966B1
公开(公告)日：2002-08-27
申请号：US09869639
申请日：2001-07-02
IPC分类号： C07D295027
CPC分类号： C07C311/39 , C07C2601/02
摘要： Benzenesulfonamides of formula (I), in which W is OR1, NR2OR1, NRARB, NR2NRARB, or NR2(CH2)2-4NRARB and the other variables as defined in the claims, are inhibitors of MEK and are effective in the treatment of proliferative diseases, cancer, stroke, heart failure, xenograft rejection, arthritis, cystic fibrosis, hepatomegaly, cardiomegaly, Alzheimer's disease, complications of diabetes, septic shock, and viral infection.
摘要翻译： 其中W是OR1，NR2OR1，NRARB，NR2NRARB或NR2（CH2）2-4NRARB的式（I）的苯磺酰胺和权利要求中定义的其它变量是MEK的抑制剂，并且在治疗增殖性疾病中是有效的 ，癌症，中风，心力衰竭，异种移植排斥，关节炎，囊性纤维化，肝肿大，心脏肥大，阿尔茨海默病，糖尿病并发症，败血性休克和病毒感染。
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公开(公告)号：US07411001B2
公开(公告)日：2008-08-12
申请号：US11102307
申请日：2005-04-07
申请人： Stephen Douglas Barrett , Cathlin Marie Biwersi , Michael Huai Gu Chen , Michael David Kaufman , Haile Tecle , Joseph Scott Warmus
发明人： Stephen Douglas Barrett , Cathlin Marie Biwersi , Michael Huai Gu Chen , Michael David Kaufman , Haile Tecle , Joseph Scott Warmus
IPC分类号： A61K31/215 , C07C239/00
CPC分类号： C07D261/02 , C07C259/10 , C07C271/16 , C07C2601/02 , C07D295/088 , C07D317/18 , C07D319/06
摘要： The present invention relates to oxygenated esters of 4-iodophenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof. The present invention also relates to crystalline forms of oxygenated esters of 4-iodophenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof.
摘要翻译： 本发明涉及4-碘苯基氨基苯并肟酸衍生物的氧化酯，药物组合物及其使用方法。 本发明还涉及4-碘苯基氨基苯并肟酸衍生物的氧化酯的结晶形式，药物组合物及其使用方法。
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