利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

13 条记录 (耗时 0.019 秒)

    Substituted imidazolinyl-imidazolines as antagonists of SH-2 binding and therapeutic uses thereof
    7.
    发明授权
    Substituted imidazolinyl-imidazolines as antagonists of SH-2 binding and therapeutic uses thereof 失效
    取代的咪唑啉基 - 咪唑啉作为SH-2结合的拮抗剂及其治疗用途

    公开(公告)号：US5721266A

    公开(公告)日：1998-02-24

    申请号：US312253

    申请日：1994-09-26

    申请人： Stuart James Decker ,  David William Fry ,  James Marino Hamby ,  Alan Robert Saltiel

    发明人： Stuart James Decker ,  David William Fry ,  James Marino Hamby ,  Alan Robert Saltiel

    IPC分类号： A61K31/4178 ,  A01N43/50

    CPC分类号： A61K31/4178

    摘要： Methods of treating proliferative diseases or viral, inflammatory, allergic and cardiovascular diseases, and restenosis are disclosed. The present invention demonstrates the use of N,N'-piperazinylbis-�2-amino-1-imidazolin-2-yl)-2-imidazolines!, 2-amino-1-(2-imidazolin-2-yl)-2-imidazolines, and N,N'-alkylene-bis�2-amino-1-(2-imidazolin-2-yl)-2-imidazolines!, their derivatives, and salts thereof, to antagonize the association of a protein tyrosine kinase with a substrate regulatory protein. The present invention also demonstrates the use of pharmaceutical compositions employing N,N'-piperazinylbis�2-amino-1-imidazolin-2-yl)-2-imidazolines!, 2-amino-1-(2-imidazolin-2-yl)-2-imidazolines, and N,N'-alkylenebis-�2-amino-1-(2-imidazolin-2-yl)-2-imidazolines!, their derivatives, and salts thereof, to antagonize the association of a protein tyrosine kinase with substrate regulatory protein. The present invention also relates to novel N,N'-piperazinylbis�2-amino-1-imidazolin-2-yl)-2-imidazolines!.

    摘要翻译： 公开了治疗增殖性疾病或病毒，炎性，过敏性和心血管疾病以及再狭窄的方法。 本发明证明了使用N，N'-哌嗪基双[2-氨基-1-咪唑啉-2-基] -2-咪唑啉]，2-氨基-1-（2-咪唑啉-2-基）-2 - 咪唑啉和N，N'-亚烷基 - 双[2-氨基-1-（2-咪唑啉-2-基）-2-咪唑啉]及其衍生物及其盐，以拮抗蛋白酪氨酸激酶 与底物调节蛋白。 本发明还说明了使用N，N'-哌嗪基双[2-氨基-1-咪唑啉-2-基] -2-咪唑啉]，2-氨基-1-（2-咪唑啉-2-基） ）-2-咪唑啉和N，N'-亚烷基双 - [2-氨基-1-（2-咪唑啉-2-基）-2-咪唑啉]及其衍生物及其盐，以拮抗蛋白质 酪氨酸激酶与底物调节蛋白。 本发明还涉及新的N，N'-哌嗪基双[2-氨基-1-咪唑啉-2-基] -2-咪唑啉]。